ArticlePLoS genetics2016
The Interplay between Myc and CTP Synthase in Drosophila.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 80 citations in OpenAlex.
- Integrative role of CTPS cytoophidia in polyploid tissue growth and nutrient adaptation.Insect science · 2026Article
- Genetic and chromatin regulation of Pvt1 monoallelic expression.Cell reports · 2025Article
- Cytoophidium complexes resonate with cell fates.Cellular and molecular life sciences : CMLS · 2025Article
- Architecture of CTPS filament networks revealed by cryo-electron tomography.Experimental cell research · 2024Article
- The Impact of Developmental and Metabolic Cues on Cytoophidium Formation.International journal of molecular sciences · 2024Review
- Dynamic Cytoophidia during Late-StageInternational journal of molecular sciences · 2024Article
- Cytoophidia: a conserved yet promising mode of enzyme regulation in nucleotide metabolism.Molecular biology reports · 2024Review
- Connecting Hippo Pathway and Cytoophidia inInternational journal of molecular sciences · 2024Article
- Cytoophidia Influence Cell Cycle and Size inInternational journal of molecular sciences · 2024Article
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- Cytoophidia Maintain the Integrity ofInternational journal of molecular sciences · 2022Article
- CTP synthase: the hissing of the cellular serpent.Histochemistry and cell biology · 2022Review
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- Cytoophidia coupling adipose architecture and metabolism.Cellular and molecular life sciences : CMLS · 2022Article
- MYC sensitises cells to apoptosis by driving energetic demand.Nature communications · 2022Article
- Polyploidy in development and tumor models in Drosophila.Seminars in cancer biology · 2022Review
- GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NHBiomolecules · 2022Review
- Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.Cancer research · 2022Article
- Formation of autotriploid Carassius auratus and its fertility-related genes analysis.BMC genomics · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
CTP synthase (CTPsyn) is essential for the biosynthesis of pyrimidine nucleotides. It has been shown that CTPsyn is incorporated into a novel cytoplasmic structure which has been termed the cytoophidium. Here, we report that Myc regulates cytoophidium formation during Drosophila oogenesis. We have found that Myc protein levels correlate with cytoophidium abundance in follicle epithelia. Reducing Myc levels results in cytoophidium loss and small nuclear size in follicle cells, while overexpression of Myc increases the length of cytoophidia and the nuclear size of follicle cells. Ectopic expression of Myc induces cytoophidium formation in late stage follicle cells. Furthermore, knock-down of CTPsyn is sufficient to suppress the overgrowth phenotype induced by Myc overexpression, suggesting CTPsyn acts downstream of Myc and is required for Myc-mediated cell size control. Taken together, our data suggest a functional link between Myc, a renowned oncogene, and the essential nucleotide biosynthetic enzyme CTPsyn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.