ArticleInternational journal of geriatric psychiatry2017
Psychotropic use and associated neuropsychiatric symptoms among patients with dementia in the USA.
Article in International journal of geriatric psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Factors Associated with Psychotropic Medication Use in People Living with Dementia in the Community: A Systematic Review and Meta-Analysis.Drugs & aging · 2023Pooled it
- Association of Focused Medication Review With Optimization of Psychotropic Drug Prescribing: A Systematic Review and Meta-analysis.JAMA network open · 2018Pooled it
- A systematic review of non-pharmacological interventions to improve nighttime sleep among residents of long-term care settings.BMC geriatrics · 2018Pooled it
- Standardizing care for agitation in Alzheimer's disease, results from a randomized controlled trial of an integrated care pathway versus usual care - the StaN trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Effect of pharmacist-led medication reviews on appropriateness of prescribing in patients with dementia - results from the cluster randomized controlled "DemStepCare" study.BMC geriatrics · 2025Trial
- A Cluster Randomized Controlled Trial Testing the Impact of Function and Behavior Focused Care for Nursing Home Residents With Dementia.Journal of the American Medical Directors Association · 2021Trial
- Effects of Caregiver Dementia Training in Caregiver-Patient Dyads on Psychotropic Drug Prescription: A Randomized Controlled Study.Clinical interventions in aging · 2021Trial
- Current Psychotropic Medication Use and Contributing Factors Among Nursing Home Residents With Cognitive Impairment.Clinical nursing research · 2021Trial
- Lack of Early Improvement with Antipsychotics is a Marker for Subsequent Nonresponse in Behavioral and Psychological Symptoms of Dementia: Analysis of CATIE-AD Data.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Trial
- Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Review
- Antidepressant Use Among US Nursing Home Residents With Dementia.Journal of the American Geriatrics Society · 2026Article
- Review
- Evaluating non-pharmacological approaches to nursing home dementia care: A protocol.Contemporary clinical trials communications · 2023Article
- Psychotropic Medication Use and Changes During Hospitalization for Older Adults Living With Dementia.Clinical nursing research · 2023Article
- Prevalences and Indications of Psychotropic Drug Prescriptions in Nursing Home Residents with Korsakoff Syndrome.Journal of clinical medicine · 2023Article
- Effects of the DICE Method to Improve Timely Recognition and Treatment of Neuropsychiatric Symptoms in Early Alzheimer's Disease at the Memory Clinic: The BEAT-IT Study.Journal of Alzheimer's disease : JAD · 2023Article
- Evaluation of Antipsychotic Reduction Efforts in Patients With Dementia in Veterans Health Administration Nursing Homes.The American journal of psychiatry · 2022Article
- Article
- Beyond the Medication Pass: Attitudes, Ethics, Agency, and Antipsychotic Medications in Assisted Living/Residential Care.Innovation in aging · 2022Article
- e-Learning and Web-Based Tools for Psychosocial Interventions Addressing Neuropsychiatric Symptoms of Dementia During the COVID-19 Pandemic in Tokyo, Japan: Quasi-Experimental Study.JMIR medical education · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo determine the national prevalence of psychotropic use and association with neuropsychiatric symptoms among patients with dementia.
methodsParticipants diagnosed with dementia (n = 414) in the Aging, Demographics, and Memory Study, a nationally representative survey of US adults >70 years old. Diagnosis was based on in-person clinical assessment and informant interview. Information collected included demographics, place of residence, 10-item Neuropsychiatric Inventory (NPI), and prescribed medications (antipsychotic, sedative-hypnotic, antidepressant, mood stabilizer).
resultsOf 414 participants with dementia, 41.4% were prescribed a psychotropic medication, including 84.0% of nursing home residents and 28.6% of community-dwellers. Of participants, 23.5% were prescribed an antidepressant. Compared with the total NPI score of those on no medication (4.5), those on antipsychotics and those on sedative-hypnotics had much higher scores (respectively: 12.6, p < 0.001; 11.8, p = 0.03), although those antidepressants did not (6.9, p = 0.15). A larger proportion of patients on antipsychotics exhibited psychosis and agitation compared with those on no medication, while those on antidepressants exhibited more depressive symptoms. In multivariable logistic regression that included dementia severity and nursing home residence, nursing home residence was the characteristic most strongly associated with psychotropic use (odds ratio ranging from 8.96 [p < 0.001] for antipsychotics to 15.59 [p < 0.001] for sedative-hypnotics). More intense psychotic symptoms and agitation were associated with antipsychotic use; more intense anxiety and agitation were associated with sedative-hypnotic use. More intense depression and apathy were not associated with antidepressant use.
conclusionsIn this nationally representative sample, 41.4% of patients were taking psychotropic medication. While associated with neuropsychiatric symptoms, nursing home residence was most strongly tied to use. Copyright © 2016 John Wiley & Sons, Ltd.
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