ArticleThe Clinical journal of pain2016
Multiple Levels of Suffering: Discrimination in Health-Care Settings is Associated With Enhanced Laboratory Pain Sensitivity in Sickle Cell Disease.
Article in The Clinical journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Depression in adults with sickle cell disease: a systematic review of the methodological issues in assessing prevalence of depression.BMC psychology · 2021Pooled it
- Pooled it
- Stigma of Sickle Cell Disease: A Systematic Review.Issues in mental health nursing · 2018Pooled it
- Bystander Acknowledgment Mitigates the Psychological and Physiological Pain of Racial Discrimination for Black Young Adults: A Randomized Controlled Trial.The journal of pain · 2024Trial
- Burning Mouth Syndrome: Understanding the Biopsychosocial Dimensions of Invisible Pain.Journal of oral rehabilitation · 2026Observational
- Association between comorbid depression, antidepressant adherence, and disease-modifying therapy adherence among Texas Medicaid patients with sickle cell disease.Journal of managed care & specialty pharmacy · 2026Article
- Sickle cell pain: call for whole person health approaches to mechanisms-informed integrative management.Blood advances · 2026Article
- Racial Disparities in Long COVID: Why Black Americans are Likely Underrepresented in Long COVID Estimates.Journal of racial and ethnic health disparities · 2026Review
- Pain expression and decoding as intergroup phenomena.Affective science · 2026Article
- Factors Affecting Pain Control in Patients with Sickle Cell Disease at Mwananyamala and Muhimbili Hospitals in Dar es Salaam, Tanzania.Journal of clinical medicine · 2026Article
- The relation between sleep and pain sensitization in pediatric sickle cell disease.Journal of pediatric psychology · 2026Article
- Leveraging insights from the psychological science of gender stereotyping to advance scholarship on gender-diverse individuals' pain experiences.The journal of pain · 2025Article
- Pain sensitisation in patients with sickle cell disease: A preliminary study.Journal of evaluation in clinical practice · 2025Article
- Racialized disparities in pain and pain care among Belgian youth.Frontiers in psychiatry · 2025Article
- Hydroxyurea utilization among individuals with sickle cell disease in Tennessee: a pooled analysis of claims data.Frontiers in pharmacology · 2025Article
- Health Care Discrimination Affects Patient Activation, Communication Self-Efficacy, and Pain for Black Americans.The journal of pain · 2024Article
- Impact of disease- and race-based discrimination in healthcare on pain outcomes among adults living with sickle cell disease in the United States: The mediating roles of internalized stigma and depressive symptoms.Stigma and health · 2024Article
- Genetic contributions to pain modulation in sickle cell: A focus on single nucleotide polymorphisms.Gene reports · 2024Article
- Prevalence and factors associated with opioid use disorder among adolescents with sickle cell disease in Mulago hospital, Uganda.Child and adolescent psychiatry and mental health · 2024Article
- Neurological care for LGBT+ people.Nature reviews. Neurology · 2024Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivePeople living with sickle cell disease (SCD) experience severe episodic and chronic pain and frequently report poor interpersonal treatment within health-care settings. In this particularly relevant context, we examined the relationship between perceived discrimination and both clinical and laboratory pain.
methodsSeventy-one individuals with SCD provided self-reports of experiences with discrimination in health-care settings and clinical pain severity, and completed a psychophysical pain testing battery in the laboratory.
resultsDiscrimination in health-care settings was correlated with greater clinical pain severity and enhanced sensitivity to multiple laboratory-induced pain measures, as well as stress, depression, and sleep. After controlling for relevant covariates, discrimination remained a significant predictor of mechanical temporal summation (a marker of central pain facilitation), but not clinical pain severity or suprathreshold heat pain response. Furthermore, a significant interaction between experience with discrimination and clinical pain severity was associated with mechanical temporal summation; increased experience with discrimination was associated with an increased correlation between clinical pain severity and temporal summation of pain. DISCUSSION: Perceived discrimination within health-care settings was associated with pain facilitation. These findings suggest that discrimination may be related to increased central sensitization among SCD patients, and more broadly that health-care social environments may interact with pain pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.