ArticleExperimental and therapeutic medicine2016
Effect of cold stress on immunity in rats.
Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Effect of Heat-TreatedNutrients · 2024Trial
- Effect of medium with moderate temperature on patient's body temperature during percutaneous endoscopic lumbar discectomy.Journal of orthopaedic surgery and research · 2022Trial
- Extreme temperatures and the epithelial barrier theory.Seminars in immunopathology · 2026Review
- Temperature extremes and autoimmune diseases.Seminars in immunopathology · 2026Review
- Comparative Study on Extracts from Traditional Medicinal PlantsPharmaceuticals (Basel, Switzerland) · 2025Article
- Impact of a sudden drop in ambient temperature on some phenotypic and functional properties of the camel's immune system.Journal of advanced veterinary and animal research · 2025Article
- Enhanced propionate and butyrate metabolism in cecal microbiota contributes to cold-stress adaptation in sheep.Microbiome · 2025Article
- Effect of environmental exposome and influenza infection on febrile seizure in children over 22 years: a time series analysis.International journal of biometeorology · 2024Article
- The Effects of Housing on Growth, Immune Function and Antioxidant Status of Young Female Lambs in Cold Conditions.Animals : an open access journal from MDPI · 2024Article
- Low ambient temperature increases hospital re-admissions for systemic lupus erythematosus in humid subtropical region: a time series study.Environmental science and pollution research international · 2021Article
- Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats.Brain, behavior, and immunity · 2020Article
- Effects of cold exposure revealed by global transcriptomic analysis in ferret peripheral blood mononuclear cells.Scientific reports · 2019Article
- Impact of mast cells in depression disorder: inhibitory effect of IL-37 (new frontiers).Immunologic research · 2018Review
- Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life.PloS one · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increase in the morbidity of upper respiratory tract infections and the attack and exacerbation of autoimmune diseases has been observed to occur in the few days following sudden environmental temperature decreases, but the mechanisms for these phenomena are not well understood. To determine the effect of a sudden ambient temperature drop on the levels of stress hormones and T-lymphocyte cytokines in the plasma, the Toll-like receptor 4 (TLR4) expression of immunocompetent cells in rat spleens and the levels of regulatory T (Treg) cells in the peripheral blood, Sprague Dawley rats were divided into three groups of different ambient temperatures (20, 4 and -12°C). In each group, there were four observation time-points (1, 12, 24 and 48 h). Each ambient temperature group was subdivided into non-stimulation, lipopolysaccharide-stimulation and concanavalin A-stimulation groups. The levels of adrenocorticotropin (ACTH), epinephrine (EPI), angiotensin-II (ANG-II), interleukin-2 (IL-2), interferon-γ (IFN-γ), IL-4 and IL-10 in the plasma were determined using ELISA. The cellular expression levels of TLR4 and the presence of cluster of differentiation (CD)4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.