Evidence map›Paper›PMID 26889206›Full record

ArticleInfectious agents and cancer2016

Prevalence of human papilloma virus (HPV) and its genotypes in cervical specimens of Egyptian women by linear array HPV genotyping test.

Mohamed A Youssef, Lobna Abdelsalam, Reem Abdelhameed Harfoush, Iman Mamdouh Talaat, Eman Elkattan, Abeer Mohey, Rana M A Abdella, Marwa Salah Farhan, Hany Ahmed Foad, Abeer Mostafa Elsayed and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious agents and cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Mohamed A YoussefDepartment of obstetrics& gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt ; Egyptian International Fertility IVF-ET center-Cairo, 16 Elhassan Ben Ali, Nast City, Cairo Egypt.
Lobna AbdelsalamDepartment of clinical & chemical pathology, Faculty of medicine, Cairo University, Cairo, Egypt.
Reem Abdelhameed HarfoushDepartment of medical microbiology & immunology, Faculty of medicine, Alexandria University, Alexandria, Egypt.
Iman Mamdouh TalaatDepartment of Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Eman ElkattanDepartment of obstetrics& gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abeer MoheyDepartment of chemical pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Rana M A AbdellaDepartment of obstetrics& gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Marwa Salah FarhanDepartment of clinical pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hany Ahmed FoadDepartment of chemical pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abeer Mostafa ElsayedDepartment of Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Naglaa A ElkinaaiDepartment of Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Doaa GhaithDepartment of clinical pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Elsayed RashedNational Organization for Research & Control of Biologicals (NORCB), Cairo, Egypt.
Mohamed Abd-El GhafarDepartment of Obstetrics& Gynecology, Beni-Suef University, Beni Suef, Egypt.
Yasser KhamisDepartment of Obstetrics& Gynecology, Beni-Suef University, Beni Suef, Egypt.
Ahmed N HosniDepartment of obstetrics& gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Cairo University · EGAlexandria University · EGBeni-Suef University · EGNational Organization for Drug Control and Research · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association of human papillomavirus (HPV) with cervical cancer is well established.

aimTo investigate HPV genotype distribution and co-infection occurrence in cervical specimens from a group of Egyptian women.

methodsA group of 152 women with and without cervical lesions were studied. All women had cervical cytology and HPV testing. They were classified according to cytology into those with normal cytology, with squamous intraepithelial lesions (SIL) and invasive squamous cell carcinoma (SCC). Cervical samples were analyzed to identify the presence of HPV by PCR, and all positive HPV-DNA samples underwent viral genotype analysis by means of LINEAR ARRAY HPV Genotyping assay.

resultsA total of 26 HPV types with a prevalence of 40.8 % were detected. This prevalence was distributed as follows: 17.7 % among cytologically normal females, 56.5, 3.2, and 22.6 % among those with LSIL, HSIL and invasive SCC respectively. Low-risk HPV types were detected in 81.8 % of the cytologically-normal women, in 5.7 % of those in LSIL women, and in 14.3 % of infections with invasive SCC, while no low-risk types were detected in HSIL. High-risk HPV types were detected in 18.2 % of infections in the cytologically normal women, 14.3 % of infections in LSIL, and in 21.4 % of invasive lesions. The probable and possible carcinogenic HPV were not detected as single infections. Mixed infection was present in 80 % of women with LSIL, in 100 % of those with HSIL, and in 64.3 % of those with invasive SCC. This difference was statistically significant. HPV 16, 18 and 31 were the most prevalent HR HPV types, constituting 41.9, 29.03 and 12.9 % respectively, and HPV 6, 62 and CP6108 were the most prevalent LR HPV types constituting 11.3, 9.7 and 9.7 % respectively.

conclusionThese data expand the knowledge concerning HPV prevalence and type distribution in Egypt which may help to create a national HPV prevention program. HPV testing using the LINEAR ARRAY HPV Genotyping assay is a useful tool when combined with cytology in the diagnosis of mixed and non-conventional HPV viral types.

Indexed as

Cervical smearCervical squamous intraepithelial lesionsHuman papillomavirus (HPV)Linear Array HPV genotyping

Identifiers

PMID26889206
PMCPMC4756400
OpenAlexW2284120387

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.