ArticleNeural regeneration research2015
A novel method for evaluating brain function and microstructural changes in Parkinson's disease.
Article in Neural regeneration research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Backward Walking as a Rehabilitation Strategy in Parkinson's Disease: A Focused Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Classification of neurodegenerative diseases using brain effective connectivity and machine learning techniques: a systematic review.Frontiers in neurology · 2025Pooled it
- White Matter Abnormalities in Patients With Parkinson's Disease: A Meta-Analysis of Diffusion Tensor Imaging Using Tract-Based Spatial Statistics.Frontiers in aging neuroscience · 2020Pooled it
- Substantia nigra fractional anisotropy is not a diagnostic biomarker of Parkinson's disease: A diagnostic performance study and meta-analysis.European radiology · 2017Pooled it
- Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Review
- Review
- Combining biomarkers for prognostic modelling of Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Utility of manual fractional anisotropy measurements in the management of patients with Parkinson disease: a feasibility study with a 1.5-T magnetic resonance imaging system.Acta radiologica open · 2021Article
- Neurocognitive and psychiatric disorders-related axonal degeneration in Parkinson's disease.Journal of neuroscience research · 2020Article
- Diffusion Tensor Imaging in Parkinson's Disease and Parkinsonian Syndrome: A Systematic Review.Frontiers in neurology · 2020Review
- Voltage adjustment improves rigidity and tremor in Parkinson's disease patients receiving deep brain stimulation.Neural regeneration research · 2018Article
- The role of diffusion magnetic resonance imaging in Parkinson's disease and in the differential diagnosis with atypical parkinsonism.Radiologia brasileiraReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, microstructural brain damage in Parkinson's disease patients was examined using diffusion tensor imaging and tract-based spatial statistics. The analyses revealed the presence of neuronal damage in the substantia nigra and putamen in the Parkinson's disease patients. Moreover, disease symptoms worsened with increasing damage to the substantia nigra, confirming that the substantia nigra and basal ganglia are the main structures affected in Parkinson's disease. We also found that microstructural damage to the putamen, caudate nucleus and frontal lobe positively correlated with depression. Based on the tract-based spatial statistics, various white matter tracts appeared to have microstructural damage, and this correlated with cognitive disorder and depression. Taken together, our results suggest that diffusion tensor imaging and tract-based spatial statistics can be used to effectively study brain function and microstructural changes in patients with Parkinson's disease. Our novel findings should contribute to our understanding of the histopathological basis of cognitive dysfunction and depression in Parkinson's disease.
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