Evidence map›Paper›PMID 26889032›Full record

ReviewJournal of virology2016

Emerging Roles of Protein Deamidation in Innate Immune Signaling.

Jun Zhao, Junhua Li, Simin Xu, Pinghui Feng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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  14. Article
  15. Review
  16. Article
  17. Early Nuclear Events after Herpesviral Infection.Journal of clinical medicine · 2019
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jun ZhaoDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.
Junhua LiDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.
Simin XuDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.
Pinghui FengDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA pinghui.feng@med.usc.edu.

Funding

Roles of the K3 and K5 in KSHV Persistence and PathogenesisP01CA180779 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2017
$7.3M
Targeting an immune kinase to purge KSHV latent infectionR01DE026003 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, CASEY, ZHANG, CHAO · 2016 to 2020
$3.4M
Proviral Roles of an Innate Immune PathwayR01DE021445 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FENG, PINGHUI · 2011 to 2017
$2.5M
Post-Translational Events Underlying the KSHV vGPCR PathogenesisR01CA134241 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FENG, PINGHUI · 2009 to 2013
$1.6M
NCI NIH HHS CA134241NCI NIH HHS P01 CA180779NCI NIH HHS R01 CA134241NIDCR NIH HHS DE021445NIDCR NIH HHS R01 DE021445NIDCR NIH HHS R01 DE026003
6 · The paper itself

Abstract

Protein deamidation has been considered a nonenzymatic process associated with protein functional decay or "aging." Recent studies implicate protein deamidation in regulating signal transduction in fundamental biological processes, such as innate immune responses. Work investigating gammaherpesviruses and bacterial pathogens indicates that microbial pathogens deploy deamidases or enzyme-deficient homologues (pseudoenzymes) to induce deamidation of key signaling components and evade host immune responses. Here, we review studies on protein deamidation in innate immune signaling and present several imminent questions concerning the roles of protein deamidation in infection and immunity.

Indexed as

Host-Pathogen InteractionsImmunity, InnateSignal TransductionAnimalsCatalysisCytokinesHumansImmune EvasionProteinsProteolysisReceptors, Pattern RecognitionReceptors, Retinoic AcidCytokinesProteinsReceptors, Pattern RecognitionReceptors, Retinoic Acid

Identifiers

PMID26889032
PMCPMC4836359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.