Evidence map›Paper›PMID 26889026›Full record

ArticleJournal of virology2016

Single-Particle Tracking Shows that a Point Mutation in the Carnivore Parvovirus Capsid Switches Binding between Host-Specific Transferrin Receptors.

Donald W Lee, Andrew B Allison, Kaitlyn B Bacon, Colin R Parrish, Susan Daniel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Donald W LeeSchool of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA.
Andrew B AllisonBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Kaitlyn B BaconSchool of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA.
Colin R ParrishBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA crp3@cornell.edu sd386@cornell.edu.ORCID http://orcid.org/0000-0002-1836-6655
Susan DanielSchool of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA crp3@cornell.edu sd386@cornell.edu.
Cornell University · US

Funding

Structural Controls of Functional Receptor and Antibody Binding to Viral Capsids.R01AI092571 · NIAID · CORNELL UNIVERSITY · PI PARRISH, COLIN R. · 2011 to 2021
$4.0M
Host cell receptor variation and control of viral cross-species transmissionF32AI100545 · NIAID · CORNELL UNIVERSITY · PI ALLISON, ANDREW BROWNELL · 2013 to 2015
$165k
NIAID NIH HHS F32 AI100545NIAID NIH HHS F32AI100545NIAID NIH HHS R01 AI092571NIGMS NIH HHS R01 GM8496821
6 · The paper itself

Abstract

Determining how viruses infect new hosts via receptor-binding mechanisms is important for understanding virus emergence. We studied the binding kinetics of canine parvovirus (CPV) variants isolated from raccoons-a newly recognized CPV host-to different carnivore transferrin receptors (TfRs) using single-particle tracking. Our data suggest that CPV may utilize adhesion-strengthening mechanisms during TfR binding and that a single mutation in the viral capsid at VP2 position 300 can profoundly alter receptor binding and infectivity.

Indexed as

Point MutationViral TropismAnimalsCapsid ProteinsCell LineDogsKineticsMicroscopy, FluorescenceMolecular ImagingParvovirus, CanineProtein BindingRaccoonsReceptors, TransferrinStaining and LabelingCapsid ProteinsReceptors, Transferrin

Identifiers

PMID26889026
PMCPMC4836364
OpenAlexW2273883501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.