ArticleJournal of the Royal Society, Interface2016
Finite-element model of the active organ of Corti.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Corti Fluid Is a Medium for Outer Hair Cell Force Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea.Communications biology · 2024Article
- An outer hair cell-powered global hydromechanical mechanism for cochlear amplification.Hearing research · 2022Article
- Design and optimization of auditory prostheses using the finite element method: a narrative review.Annals of translational medicine · 2022Review
- Microstructural interactions contribute to the hotspot in the living cochlea.Current research in neurobiology · 2022Article
- A flexible anatomical set of mechanical models for the organ of Corti.Royal Society open science · 2021Article
- Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.Developmental cell · 2021Article
- Correlating Cochlear Morphometrics from Parnell's Mustached Bat (Pteronotus parnellii) with Hearing.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Critical role of spectrin in hearing development and deafness.Science advances · 2019Article
- Drug Diffusion Along an Intact Mammalian Cochlea.Frontiers in cellular neuroscience · 2019Article
- Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae.eLife · 2018Article
- Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- An elemental approach to modelling the mechanics of the cochlea.Hearing research · 2018Review
- Analytical and numerical modeling of the hearing system: Advances towards the assessment of hearing damage.Hearing research · 2017Review
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Authors and funding
3 authors.
Funding
Abstract
The cochlear amplifier that provides our hearing with its extraordinary sensitivity and selectivity is thought to be the result of an active biomechanical process within the sensory auditory organ, the organ of Corti. Although imaging techniques are developing rapidly, it is not currently possible, in a fully active cochlea, to obtain detailed measurements of the motion of individual elements within a cross section of the organ of Corti. This motion is predicted using a two-dimensional finite-element model. The various solid components are modelled using elastic elements, the outer hair cells (OHCs) as piezoelectric elements and the perilymph and endolymph as viscous and nearly incompressible fluid elements. The model is validated by comparison with existing measurements of the motions within the passive organ of Corti, calculated when it is driven either acoustically, by the fluid pressure or electrically, by excitation of the OHCs. The transverse basilar membrane (BM) motion and the shearing motion between the tectorial membrane and the reticular lamina are calculated for these two excitation modes. The fully active response of the BM to acoustic excitation is predicted using a linear superposition of the calculated responses and an assumed frequency response for the OHC feedback.
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