ArticleInternational journal of colorectal disease2016
Malnutrition in rectal cancer patients receiving preoperative chemoradiotherapy is common and associated with treatment tolerability and anastomotic leakage.
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03930888 (Nutritional Support and Its Influence on the Reduction of Muscle Strength, Muscle Mass and Self-sufficiency in Patients Undergoing Surgical Treatment of Colorectal Cancer), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional Support and Its Influence on the Reduction of Muscle Strength, Muscle Mass and Self-sufficiency in Patients Undergoing Surgical Treatment of Colorectal Cancer
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Effect of powered circular stapler in colorectal anastomosis after left-sided colic resection: systematic review and meta-analysis.International journal of colorectal disease · 2024Pooled it
- Pretreatment comprehensive nutritional index predicts survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and surgery.Biomolecules & biomedicine · 2026Article
- High versus low ligation of the inferior mesenteric artery during transanal total mesorectal excision for low rectal cancer: impact on postoperative anastomotic leakage.Frontiers in oncology · 2026Article
- The prognosis value of geriatric nutritional risk index and associated genes in elderly patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy.Nutrition journal · 2025Article
- Impact of Circular Stapler Diameter on Anastomotic Leakage in Left-Sided Colorectal Cancer: A Retrospective Single-Center Case-Control Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Clinical anastomosis leakage and determinant factors among patients who underwent intestinal anastomosis in two Ethiopian tertiary hospitals.BMC gastroenterology · 2025Article
- Awareness and usage of a dietary guide by cancer patients and clinicians: a national survey study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Methods for diagnosing malnutrition in patients with esophageal cancer, and the association with nutritional and inflammatory indices: A cross‑sectional study.Oncology letters · 2025Article
- Machine learning and deep learning to improve prevention of anastomotic leak after rectal cancer surgery.World journal of gastrointestinal surgery · 2025Article
- Effects of Diverting Stoma Creation in Minimally Invasive Surgery for Rectal Cancer.Journal of the anus, rectum and colon · 2025Article
- Nutritional assessments and interventions in head and neck, esophageal, rectal and lung cancers undergoing anticancer treatments: a literature review.Frontiers in oncology · 2025Review
- Prophylactic defunctioning stomas improve clinical outcomes of anastomotic leak following rectal cancer resections: An analysis of the US Rectal Cancer Consortium.International journal of colorectal disease · 2024Article
- A large-scale study integrating nutritional indicators and clinicopathological parameters to evaluate prognosis, follow-up, and postoperative chemotherapy decisions in rectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- The clinical predictive value of geriatric nutritional risk index in elderly rectal cancer patients received surgical treatment after neoadjuvant therapy.Frontiers in nutrition · 2023Article
- Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer.Frontiers in oncology · 2023Article
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- Article
- Observational
- Is hand grip strength a necessary supportive index in the phenotypic criteria of the GLIM-based diagnosis of malnutrition in patients with cancer?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Risk Factors for Anastomotic Leakage in Patients with Rectal Tumors Undergoing Anterior Resection within an ERAS Protocol: Results from the Swedish ERAS Database.World journal of surgery · 2021Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study assessed the incidence of malnutrition caused by preoperative chemoradiotherapy (CRT) in rectal cancer patients, which is seemingly underestimated; however, malnutrition affects treatment tolerability, postoperative complications, including anastomotic leakage (AL), and oncological outcomes.
methodsBetween January 2008 and December 2014, 54 consecutive patients with T3-4, N0-2, M0-1 resectable rectal cancer received CRT comprising 45 Gy radiotherapy and S-1 alone or with irinotecan for 5 weeks and then underwent curative surgery with diverting or permanent stomas 6-8 weeks after CRT. We assessed malnutrition after completion of CRT (5-6 weeks after CRT start date) and at surgery (11-14 weeks after CRT start date), defining weight loss as ≥5 % of pre-CRT weight; this definition differs from commonly used criteria for adverse events. We evaluated the incidence of malnutrition associated with CRT and influence of malnutrition on treatment tolerability, AL, and disease-free survival (DFS). We also assessed the influence of CRT on the rate of postoperative complications by comparing the study group with 61 patients who had undergone excision with diverting or permanent stomas alone.
resultsMalnutrition was observed in 51 % of patients after CRT and in 29 % at surgery. Malnutrition after CRT was associated with treatment tolerability, and malnutrition at surgery was significantly associated with AL, which significantly influenced DFS in stage 1-3 patients.
conclusionMalnutrition caused by CRT is common and is associated with treatment tolerability and AL. Nutritional assessment and support seem indispensable for the rectal cancer patients receiving CRT.
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