Trial reportThe Journal of bone and joint surgery. American volume2016
Motion Predicts Clinical Callus Formation: Construct-Specific Finite Element Analysis of Supracondylar Femoral Fractures.
Trial report in The Journal of bone and joint surgery. American volume, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dynamic Fracture Fixation Plates: A Systematic Review of Evolving Design Approaches.Annals of biomedical engineering · 2025Pooled it
- Mechanical effects of valgus osteotomy angle and re-fixation strategies on re-fixation of the femoral neck fracture: a finite element analysis.BMC musculoskeletal disorders · 2026Article
- Callus formation during healing is guided by local strain: a retrospective clinical observation.BMC musculoskeletal disorders · 2026Observational
- Flexure-Based Locking Plates Can Modulate Interfragmentary Motion in Distal Femur and Diaphyseal Fractures: A Parametric Finite Element Analysis.Journal of biomechanical engineering · 2026Article
- Finite element andFrontiers in bioengineering and biotechnology · 2026Article
- [Establishment and comparative analysis of femoral biomechanical equivalent model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Finite element analysis of different cephalomedullary nail treatments for basicervical femoral neck fracture.Scientific reports · 2025Article
- The Effect of Plate Working Length on Interfragmentary Movement in a Distal Femoral Fracture: A Biomechanical Study.Cureus · 2025Article
- Effects of Plate-Bone Contact on Bridge Plate Fracture Fixation Biomechanics: Computational, Experimental, and Analytical Modeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Biomechanical effects of six internal fixation methods for distal femoral AO/OTA 33C1 fractures: finite element analysis.BMC musculoskeletal disorders · 2025Article
- Finite element analysis of anterior spanning attachment devices for supporting biomechanical stability in diaphyseal femoral periprosthetic fracture fixation.Scientific reports · 2025Article
- Lateral Cortical Fixation as the Optimal Strategy for Achieving Stability in Rib Fractures: A Patient-Specific Finite Element Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Modification of a Two-Part Cancellous Locking Screw: A Pilot Study on Increasing Resistance to Axial Pullout Strength.Bioengineering (Basel, Switzerland) · 2025Article
- A biomechanical study of locking spongious screws and failure rates are higher than expected in plate fixation.Scientific reports · 2025Article
- A novel nail-plate construct for the treatment of AO/OTA 31-A3.3 intertrochanteric fractures: a finite element analysis.Frontiers in bioengineering and biotechnology · 2025Article
- Quantitative biomechanical analysis of fracture patterns in ipsilateral femoral neck and shaft fractures: an in-silico study.Frontiers in bioengineering and biotechnology · 2025Article
- Mechanically compliant locking plates for diaphyseal fracture fixation: A biomechanical study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Computational evaluation of the biomechanical effects of position changes in the femoral neck system on Pauwels type III femoral neck fractures: an in silico study.Frontiers in bioengineering and biotechnology · 2025Article
- Patient-specific finite element analysis of four different fixation methods for transversely unstable radial head fractures.Scientific reports · 2024Article
- Locked plate constructs are not necessarily stiffer than nonlocked constructs: A biomechanical investigation of locked versus nonlocked diaphyseal fixation in a human cadaveric model of nonosteoporotic and osteoporotic distal femoral fractures.OTA international : the open access journal of orthopaedic trauma · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundMechanotransduction is theorized to influence fracture-healing, but optimal fracture-site motion is poorly defined. We hypothesized that three-dimensional (3-D) fracture-site motion as estimated by finite element (FE) analysis would influence callus formation for a clinical series of supracondylar femoral fractures treated with locking-plate fixation.
methodsConstruct-specific FE modeling simulated 3-D fracture-site motion for sixty-six supracondylar femoral fractures (OTA/AO classification of 33A or 33C) treated at a single institution. Construct stiffness and directional motion through the fracture were investigated to assess the validity of construct stiffness as a surrogate measure of 3-D motion at the fracture site. Callus formation was assessed radiographically for all patients at six, twelve, and twenty-four weeks postoperatively. Univariate and multivariate linear regression analyses examined the effects of longitudinal motion, shear (transverse motion), open fracture, smoking, and diabetes on callus formation. Construct types were compared to determine whether their 3-D motion profile was associated with callus formation.
resultsShear disproportionately increased relative to longitudinal motion with increasing bridge span, which was not predicted by our assessment of construct stiffness alone. Callus formation was not associated with open fracture, smoking, or diabetes at six, twelve, or twenty-four weeks. However, callus formation was associated with 3-D fracture-site motion at twelve and twenty-four weeks. Longitudinal motion promoted callus formation at twelve and twenty-four weeks (p = 0.017 for both). Shear inhibited callus formation at twelve and twenty-four weeks (p = 0.017 and p = 0.022, respectively). Titanium constructs with a short bridge span demonstrated greater longitudinal motion with less shear than did the other constructs, and this was associated with greater callus formation (p < 0.001).
conclusionsIn this study of supracondylar femoral fractures treated with locking-plate fixation, longitudinal motion promoted callus formation, while shear inhibited callus formation. Construct stiffness was found to be a poor surrogate of fracture-site motion. Future implant design and operative fixation strategies should seek to optimize 3-D fracture-site motion rather than rely on surrogate measures such as axial stiffness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.