ArticleBMC complementary and alternative medicine2016
Relationship between total phenolic contents and biological properties of propolis from 20 different regions in South Korea.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 88 citations in OpenAlex.
- Antibacterial, Phytochemical, and Antioxidant Properties of Propolis Extracts Obtained Using Different Solvents Against Multidrug-Resistant Bacteria.Pathogens (Basel, Switzerland) · 2026Article
- In Situ ThaiPharmaceuticals (Basel, Switzerland) · 2026Article
- Comparative Molecular Profiling and Bioactivity Analysis of Algerian Propolis: Antioxidant, Antibacterial Activities, and In Silico NRF2-KEAP1 Pathway Modulation.Current issues in molecular biology · 2025Article
- Evaluation of Antioxidant and Enzyme Inhibition Properties of Siran Propolis: Correlations With Phenolic Content Determined by LC-MS/MS.Food science & nutrition · 2025Article
- Phenolic Content, Antioxidant Activity and In Vitro Anti-Inflammatory and Antitumor Potential of Selected Bulgarian Propolis Samples.Biomedicines · 2025Article
- Hive Products: Composition, Pharmacological Properties, and Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The evaluation of L-arginine solution as a solvent for propolis extraction: The phenolic profile, antioxidant, antibacterial activity, and in vitro bioaccessibility.Food science & nutrition · 2024Article
- Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis.Food science & nutrition · 2023Article
- Biological Activity and Chemical Composition of Propolis from Various Regions of Poland.Molecules (Basel, Switzerland) · 2022Article
- Quality assessment and chemical diversity of Australian propolis from Apis mellifera bees.Scientific reports · 2022Article
- Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds.Journal of agricultural and food chemistry · 2022Review
- In-vitro antioxidant, in-vivo anti-inflammatory, and acute toxicity study of Indonesian propolis capsule fromSaudi journal of biological sciences · 2022Article
- Physicochemical characterization andVeterinary world · 2022Article
- Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria.Antibiotics (Basel, Switzerland) · 2022Article
- Determination of Phenolic Compounds in Various Propolis Samples Collected from an African and an Asian Region and Their Impact on Antioxidant and Antibacterial Activities.Molecules (Basel, Switzerland) · 2021Article
- Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties.Antibiotics (Basel, Switzerland) · 2021Review
- Feasibility of Sijunzi Tang (Chinese medicine) to enhance protein disulfide isomerase activities for reactivating malate dehydrogenase deactivated by polycyclic aromatic hydrocarbons.Environmental science and pollution research international · 2021Article
- The Isorhamnetin-Containing Fraction of Philippine Honey Produced by the Stingless BeeMolecules (Basel, Switzerland) · 2021Article
- Determination of antioxidant activity and phenolic compounds for basic standardization of Turkish propolis.Applied biological chemistry · 2021Article
- The botanical origin and antioxidant, anti-BACE1 and antiproliferative properties of bee pollen from different regions of South Korea.BMC complementary medicine and therapies · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPropolis (or bee glue), collected from botanical sources by honey bee, has been used as a popular natural remedies in folk medicine throughout the world. This study was conducted to assess growth inhibitory effects of ethanol extracts of propolis (EEPs) from 20 different regions in South Korea on human intestinal bacteria as well as their human β-amyloid precursor cleavage enzyme (BACE-1), acetylcholinesterase (AChE) inhibitory, antioxidant, antiproliferative, and anti-human rhinovirus activities.
methodsThe Bonferroni multiple-comparison method was used to test for significant differences in total polyphenol and flavonoid contents among EEP samples using SAS 9.13 program. Correlation coefficient (r) analysis of the biological activities of EEP samples was determined using their 50 % inhibition concentration or minimal inhibitory concentration values and their polyphenol or flavonoid contents in 20 native Korean EEP samples.
resultsThe amounts of total polyphenol and flavonoids in the Korean EEP samples ranged from 49 to 239 mg gallic acid equivalent (GAE)/g EEP (Brazilian, Chinese, and Australian samples, 127-142 mg GAE/g EEP) and from 21 to 50 mg quercetin equivalent (QE)/g EEP (Brazilian, Chinese, and Australian samples, 33-53 mg QE/g EEP), respectively. Correlation coefficient analysis showed that total polyphenol contents may be negatively correlated with 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (r = -0.872) and total flavonoid content has no correlation with the activity (r = 0.071). No direct correlation between BACE-1 inhibition, AChE inhibition, or antiproliferative activity and total polyphenol or total flavonoid content in Korean EEP samples was found. Gram-positive and Gram-negative bacteria were observed to have different degrees of antimicrobial susceptibility to the EEP samples examined, although ciprofloxacin susceptibility among the bacterial groups did not differ greatly.
conclusionsFurther studies will warrant possible applications of propolis as potential therapeutic BACE-1 blocker, antioxidant, antiproliferative agent, and antimicrobial agent.
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