ArticleSexually transmitted infections2016
Mass drug administration of azithromycin for trachoma reduces the prevalence of genital Chlamydia trachomatis infection in the Solomon Islands.
Article in Sexually transmitted infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- National progress towards the elimination of trachomatous inflammation-follicular: analysis of 11 regions in Ethiopia.International health · 2026Article
- Corneal pannus, Herbert's pits and conjunctival inflammation in older children in Papua New Guinea.Ophthalmic epidemiology · 2024Article
- Mass drug administration of antibacterials: weighing the evidence regarding benefits and risks.Infectious diseases of poverty · 2022Review
- Are current preventive chemotherapy strategies for controlling and eliminating neglected tropical diseases cost-effective?BMJ global health · 2021Review
- Prevalence of and risk factors for curable sexually transmitted infections on Bubaque Island, Guinea Bissau.Sexually transmitted infections · 2021Article
- The Importance of Failure: How Doing Impact Surveys That Fail Saves Trachoma Programs Money.The American journal of tropical medicine and hygiene · 2020Article
- Malaria and curable sexually transmitted infections in pregnant women: A two-years observational study in rural Burkina Faso.PloS one · 2020Observational
- Impact of mass drug administration of azithromycin for trachoma elimination on prevalence and azithromycin resistance of genitalSexually transmitted infections · 2019Article
- Prevalence of Trachoma and Access to Water and Sanitation in Benue State, Nigeria: Results of 23 Population-Based Prevalence Surveys.Ophthalmic epidemiology · 2018Article
- One round of azithromycin MDA adequate to interrupt transmission in districts with prevalence of trachomatous inflammation-follicular of 5.0-9.9%: Evidence from Malawi.PLoS neglected tropical diseases · 2018Article
- Clinical signs of trachoma are prevalent among Solomon Islanders who have no persistent markers of prior infection withWellcome open research · 2018Article
- The global burden of disease study 2013: What does it mean for the NTDs?PLoS neglected tropical diseases · 2017Article
- Population-Based Trachoma Mapping in Six Evaluation Units of Papua New Guinea.Ophthalmic epidemiology · 2016Article
- Mapping Trachoma in the Solomon Islands: Results of Three Baseline Population-Based Prevalence Surveys Conducted with the Global Trachoma Mapping Project.Ophthalmic epidemiology · 2016Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesChlamydia trachomatis is the most common bacterial sexually transmitted infection and is frequently asymptomatic; ocular C. trachomatis strains cause trachoma. Mass drug administration (MDA) of azithromycin for trachoma might also reduce the prevalence of genital C. trachomatis. In a survey conducted in the Solomon Islands in 2014, prior to MDA, the prevalence of genital C. trachomatis was 20.3% (95% CI 15.9% to 25.4%). We conducted a survey to establish the impact of MDA with azithromycin on genital C. trachomatis.
methodsWomen attending three community outpatient clinics, predominantly for antenatal care, 10 months after MDA with azithromycin given for trachoma elimination, were enrolled in this survey. Self-taken high vaginal swabs were for C. trachomatis and Neisseria gonorrhoeae using the BD Probetec strand displacement assay.
results298 women were enrolled. C. trachomatis infection was diagnosed in 43 women (14.4%, 95% CI 10.6% to 18.9%) and N. gonorrhoeae in 9 (3%, 95% CI 1.4% to 5.7%). The age-adjusted OR for C. trachomatis infection was consistent with a significant decrease in the prevalence of C. trachomatis following MDA (OR 0.58, 95% CI 0.37 to 0.94, p=0.027). There was no change in the prevalence of N. gonorrhoeae between following MDA (OR 0.51, 95% CI 0.22 to 1.22, p=0.13).
conclusionsThis study demonstrated a 40% reduction in the age-adjusted prevalence of genital C. trachomatis infection following azithromycin MDA for trachoma elimination.
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