ArticleParasitology2016
Impact of chemical structure of flavanol monomers and condensed tannins on in vitro anthelmintic activity against bovine nematodes.
Article in Parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Anti-parasitic activity of pelleted sainfoin (Onobrychis viciifolia) against Ostertagia ostertagi and Cooperia oncophora in calves.Parasites & vectors · 2016Trial
- Article
- The Role of Natural Anthelmintics in Small Ruminant Health: A Global Narrative Review.Animals : an open access journal from MDPI · 2026Review
- Utilization of wild desert plant extracts for theJournal of advanced veterinary and animal research · 2025Article
- Exploring the Interactions between Plant Proanthocyanidins and Thiabendazole: Insights from Isothermal Titration Calorimetry.Molecules (Basel, Switzerland) · 2024Article
- The Autoxidized Mixture of (-)-Epicatechin Contains Procyanidins and Shows Antiproliferative and Apoptotic Activity in Breast Cancer Cells.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Influence of fecal fermentation on the anthelmintic activity of proanthocyanidins and ellagitannins against human intestinal nematodes andFrontiers in pharmacology · 2024Article
- Antiparasitic Tannin-Rich Plants from the South of Europe for Grazing Livestock: A Review.Animals : an open access journal from MDPI · 2023Review
- Comparative Metabolomic Analysis of Four Fabaceae and Relationship to In Vitro Nematicidal Activity againstMolecules (Basel, Switzerland) · 2022Article
- Administration of spruce bark (Picea abies) extracts in young lambs exhibits anticoccidial effects but reduces milk intake and body weight gain.Acta veterinaria Scandinavica · 2022Article
- Impact of Sainfoin (Pathogens (Basel, Switzerland) · 2022Article
- Use of agro-industrial by-products containing tannins for the integrated control of gastrointestinal nematodes in ruminants.Parasite (Paris, France) · 2022Review
- Extracts of pine bark (Pinus sylvestris) inhibit Cryptosporidium parvum growth in cell culture.Parasitology research · 2021Article
- Chemical Analysis and Anthelmintic Activity AgainstFrontiers in veterinary science · 2021Article
- Biological Function of Plant Tannin and Its Application in Animal Health.Frontiers in veterinary science · 2021Review
- Distribution of Protein Precipitation Capacity within Variable Proanthocyanidin Fingerprints.Molecules (Basel, Switzerland) · 2020Article
- The Occurrence, Biosynthesis, and Molecular Structure of Proanthocyanidins and Their Effects on Legume Forage Protein Precipitation, Digestion and Absorption in the Ruminant Digestive Tract.International journal of molecular sciences · 2017Review
- Identification of Structural Features of Condensed Tannins That Affect Protein Aggregation.PloS one · 2017Article
- Transcriptome analysis reveals molecular anthelmintic effects of procyanidins in C. elegans.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants containing condensed tannins (CT) may have potential to control gastrointestinal nematodes (GIN) of cattle. The aim was to investigate the anthelmintic activities of four flavan-3-ols, two galloyl derivatives and 14 purified CT fractions, and to define which structural features of CT determine the anti-parasitic effects against the main cattle nematodes. We used in vitro tests targeting L1 larvae (feeding inhibition assay) and adults (motility assay) of Ostertagia ostertagi and Cooperia oncophora. In the larval feeding inhibition assay, O. ostertagi L1 were significantly more susceptible to all CT fractions than C. oncophora L1. The mean degree of polymerization of CT (i.e. average size) was the most important structural parameter: large CT reduced larval feeding more than small CT. The flavan-3-ols of prodelphinidin (PD)-type tannins had a stronger negative influence on parasite activity than the stereochemistry, i.e. cis- vs trans-configurations, or the presence of a gallate group. In contrast, for C. oncophora high reductions in the motility of larvae and adult worms were strongly related with a higher percentage of PDs within the CT fractions while there was no effect of size. Overall, the size and the percentage of PDs within CT seemed to be the most important parameters that influence anti-parasitic activity.
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