ArticleJournal of the International Neuropsychological Society : JINS2016
Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition.
Article in Journal of the International Neuropsychological Society : JINS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults.Neurobiology of aging · 2024Article
- Age affects white matter microstructure and episodic memory across the older adult lifespan.Neurobiology of aging · 2021Article
- Advances in functional and diffusion neuroimaging research into the long-term consequences of very preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Contribution of Gray Matter Atrophy and White Matter Damage to Cognitive Impairment in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Splenial white matter integrity is associated with memory impairments in posterior cortical atrophy.Brain communications · 2021Article
- Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review.Brain connectivity · 2020Review
- Dentate Gyrus Volume Mediates the Effect of Fornix Microstructure on Memory Formation in Older Adults.Frontiers in aging neuroscience · 2020Article
- Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults.Neurobiology of aging · 2019Article
- Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency.Journal of pineal research · 2019Article
- Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Longitudinal white matter microstructural change in Parkinson's disease.Human brain mapping · 2018Article
- Differences in white matter structure and cortical thickness between patients with traumatic and idiopathic chronic neck pain: Associations with cognition and pain modulation?Human brain mapping · 2018Article
- Evaluation of striatonigral connectivity using probabilistic tractography in Parkinson's disease.NeuroImage. Clinical · 2017Article
- Precommissural and postcommissural fornix microstructure in healthy aging and cognition.Brain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivesThe purpose of this study was to assess whether age-related differences in white matter microstructure are associated with altered task-related connectivity during episodic recognition.
methodsUsing functional magnetic resonance imaging and diffusion tensor imaging from 282 cognitively healthy middle-to-late aged adults enrolled in the Wisconsin Registry for Alzheimer's Prevention, we investigated whether fractional anisotropy (FA) within white matter regions known to decline with age was associated with task-related connectivity within the recognition network.
resultsThere was a positive relationship between fornix FA and memory performance, both of which negatively correlated with age. Psychophysiological interaction analyses revealed that higher fornix FA was associated with increased task-related connectivity amongst the hippocampus, caudate, precuneus, middle occipital gyrus, and middle frontal gyrus. In addition, better task performance was associated with increased task-related connectivity between the posterior cingulate gyrus, middle frontal gyrus, cuneus, and hippocampus.
conclusionsThe findings indicate that age has a negative effect on white matter microstructure, which in turn has a negative impact on memory performance. However, fornix microstructure did not significantly mediate the effect of age on performance. Of interest, dynamic functional connectivity was associated with better memory performance. The results of the psychophysiological interaction analysis further revealed that alterations in fornix microstructure explain-at least in part-connectivity among cortical regions in the recognition memory network. Our results may further elucidate the relationship between structural connectivity, neural function, and cognition.
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