ReviewJournal of the International Neuropsychological Society : JINS2016
Traumatic Brain Injury as a Disorder of Brain Connectivity.
Review in Journal of the International Neuropsychological Society : JINS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 3 syntheses or guidelines pooled it, 240 citations in OpenAlex.
- The Scale of Neurodegeneration in Moderate-to-Severe Traumatic Brain Injury: A Systematic Review of Longitudinal Studies.Annals of neurology · 2025Pooled it
- Drivers of resting-state fMRI heterogeneity in traumatic brain injury across injury characteristics and imaging methods: a systematic review and semiquantitative analysis.Frontiers in neurology · 2024Pooled it
- The Effects of Moderate-to-Severe Traumatic Brain Injury on Episodic Memory: a Meta-Analysis.Neuropsychology review · 2019Pooled it
- Heart Rate Variability Biofeedback for Mild Traumatic Brain Injury: A Randomized-Controlled Study.Applied psychophysiology and biofeedback · 2023Trial
- Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury.Neural plasticity · 2021Trial
- A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses.Advanced healthcare materials · 2026Article
- Transdiagnostic MRI-derived Features of Psychopathology Following Traumatic Brain Injury: A Systematic Review.Neuropsychology review · 2026Review
- Transglutaminase 2 Deletion Enhances Astrocyte-to-Neuron Metabolic Support and Attenuates Subacute Pathology Following Repetitive Mild Traumatic Brain Injury.bioRxiv : the preprint server for biology · 2026Article
- Focused ultrasound-induced cavitation in a human brain microphysiological system produces injury signaling biomarkers consistent with blast trauma.npj biomedical innovations · 2026Article
- Traumatic Brain Injury-Induced White Matter Disruption and Its Impact on Information Processing Speed-Theoretical and Clinical Implications: A Selective Review.Journal of clinical medicine · 2026Review
- Moderate-severe traumatic brain injury disrupts core mechanisms of online language processing and use.Cortex; a journal devoted to the study of the nervous system and behavior · 2026Article
- From Traumatic Brain Injury to Alzheimer's Disease: Multilevel Biomechanical, Neurovascular, and Molecular Mechanisms with Emerging Therapeutic Directions.International journal of molecular sciences · 2026Review
- Characterizing Continuous and Discrete Hybrid Latent Spaces for Structural Connectomes.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Secondary thalamic neuroinflammation associates with disturbed corticothalamic connectivity in a model of severe traumatic brain injury in male rats-a longitudinal study.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Relating brain function to cognitive-visuomotor integration performance in working-aged adults with persisting concussion symptoms.Frontiers in human neuroscience · 2026Article
- Progressive lifespan modifications in the corpus callosum following a single concussion in juvenile male mice monitored by diffusion MRI.Experimental neurology · 2025Article
- Long-lasting neurobehavioral disorders after traumatic brain injury: potential predictors and functional outcomes.European journal of physical and rehabilitation medicine · 2025Observational
- White Matter Integrity in Women with Repetitive Traumatic Brain Injury due to Intimate Partner Violence.Journal of neurotrauma · 2025Article
- 3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Reduced temporal organization of narrative recall in adults with moderate-severe traumatic brain injury.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesRecent advances in neuroimaging methodologies sensitive to axonal injury have made it possible to assess in vivo the extent of traumatic brain injury (TBI) -related disruption in neural structures and their connections. The objective of this paper is to review studies examining connectivity in TBI with an emphasis on structural and functional MRI methods that have proven to be valuable in uncovering neural abnormalities associated with this condition.
methodsWe review studies that have examined white matter integrity in TBI of varying etiology and levels of severity, and consider how findings at different times post-injury may inform underlying mechanisms of post-injury progression and recovery. Moreover, in light of recent advances in neuroimaging methods to study the functional connectivity among brain regions that form integrated networks, we review TBI studies that use resting-state functional connectivity MRI methodology to examine neural networks disrupted by putative axonal injury.
resultsThe findings suggest that TBI is associated with altered structural and functional connectivity, characterized by decreased integrity of white matter pathways and imbalance and inefficiency of functional networks. These structural and functional alterations are often associated with neurocognitive dysfunction and poor functional outcomes.
conclusionsTBI has a negative impact on distributed brain networks that lead to behavioral disturbance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.