ArticleScientific reports2016
A novel transcription factor gene FHS1 is involved in the DNA damage response in Fusarium graminearum.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Arsenic Resistance Protein BcArs2 Modulates Endogenous ROS Homeostasis in Infection Cushions to Enhance the Virulence of Botrytis cinerea Toward Host Plants.Molecular plant pathology · 2026Article
- A combined transcriptomic and physiological approach to understanding the adaptive mechanisms to cope with oxidative stress inMicrobiology spectrum · 2023Article
- Conservation and Expansion of Transcriptional Factor Repertoire in theJournal of fungi (Basel, Switzerland) · 2023Article
- Conservation and Expansion of Transcriptional Factor Repertoire in thebioRxiv : the preprint server for biology · 2023Article
- Fungal Zn(II)Antimicrobial agents and chemotherapy · 2021Article
- A Phenome-Wide Association Study of the Effects ofFrontiers in microbiology · 2021Article
- Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum.Scientific reports · 2020Article
- Article
- Identification and Characterization of a Novel Basic Helix-Loop-Helix Transcription Factor of Phospholipid Synthesis Regulation inFrontiers in microbiology · 2019Article
- Article
- Cooperative interactions between seed-borne bacterial and air-borne fungal pathogens on rice.Nature communications · 2018Article
- Comparative Genomics of Pathogenic and Nonpathogenic Beetle-Vectored Fungi in the Genus Geosmithia.Genome biology and evolution · 2017Article
- Large-scale molecular genetic analysis in plant-pathogenic fungi: a decade of genome-wide functional analysis.Molecular plant pathology · 2017Review
- Morphological and Transcriptomic Analysis Reveals the Osmoadaptive Response of Endophytic FungusFrontiers in microbiology · 2017Article
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8 authors.
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Abstract
Cell cycle regulation and the maintenance of genome integrity are crucial for the development and virulence of the pathogenic plant fungus Fusarium graminearum. To identify transcription factors (TFs) related to these processes, four DNA-damaging agents were applied to screen a F. graminearum TF mutant library. Sixteen TFs were identified to be likely involved in DNA damage responses. Fhs1 is a fungal specific Zn(II)2Cys6 TF that localises exclusively to nuclei. fhs1 deletion mutants were hypersensitive to hydroxyurea and defective in mitotic cell division. Moreover, deletion of FHS1 resulted in defects in perithecia production and virulence and led to the accumulation of DNA damage. Our genetic evidence demonstrated that the FHS1-associated signalling pathway for DNA damage response is independent of the ATM or ATR pathways. This study identified sixteen genes involved in the DNA damage response and is the first to characterise the novel transcription factor gene FHS1, which is involved in the DNA damage response. The results provide new insights into mechanisms underlying DNA damage responses in fungi, including F. graminearum.
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