Evidence map›Paper›PMID 26888587›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016

Effects of Continuous Positive Airway Pressure on Cognitive and Functional Outcome of Stroke Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial.

Justine A Aaronson, Winni F Hofman, Coen A M van Bennekom, Tijs van Bezeij, Joost G van den Aardweg, Erny Groet, Wytske A Kylstra, Ben Schmand

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04212260 (Strengthening Oropharyngeal Muscles as a Novel Approach to Treat Obstructive Sleep Apnea After Stroke), which is not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04212260 nacompletednot on this mapstarted 2019, after this paper: background citation

Strengthening Oropharyngeal Muscles as a Novel Approach to Treat Obstructive Sleep Apnea After Stroke: A Randomized Feasibility Study

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2019 to 2022Enrolled33ConditionsApnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, StrokeArmsOropharyngeal exercises, Sham control
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Positive airway pressure therapy for post-stroke sleep disordered breathing: a systematic review, meta-analysis and meta-regression.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Role of Positive Airway Pressure Therapy for Obstructive Sleep Apnea in Patients With Stroke: A Randomized Controlled Trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Trial
  8. Redefining Obstructive Sleep Apnea: Treatment in the Modern Era.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. A New Window to the Brain: Exosomes as a Promising Approach to Understand Mechanisms of Cognitive Deficits Associated With Obstructive Sleep Apnea.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Article
  18. Review
  19. Review
  20. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Justine A AaronsonHeliomare Research & Development and Heliomare Rehabilitation, Wijk aan Zee, Netherlands (institution at which the work was performed).
Winni F HofmanDepartment of Psychology, Brain and Cognition group, University of Amsterdam, Amsterdam, Netherlands.
Coen A M van BennekomHeliomare Research & Development and Heliomare Rehabilitation, Wijk aan Zee, Netherlands (institution at which the work was performed).
Tijs van BezeijHeliomare Research & Development and Heliomare Rehabilitation, Wijk aan Zee, Netherlands (institution at which the work was performed).
Joost G van den AardwegDepartment of Pulmonary Medicine, Medical Center Alkmaar, Alkmaar, Netherlands.
Erny GroetHeliomare Research & Development and Heliomare Rehabilitation, Wijk aan Zee, Netherlands (institution at which the work was performed).
Wytske A KylstraHeliomare Research & Development and Heliomare Rehabilitation, Wijk aan Zee, Netherlands (institution at which the work was performed).
Ben SchmandDepartment of Psychology, Brain and Cognition group, University of Amsterdam, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) in stroke patients is associated with worse functional and cognitive status during inpatient rehabilitation. We hypothesized that a four-week period of continuous positive airway pressure (CPAP) treatment would improve cognitive and functional outcomes.

methodsWe performed a randomized controlled trial in stroke patients admitted to a neurorehabilitation unit. Patients were assigned to rehabilitation treatment as usual (control group) or to CPAP treatment (CPAP group). Primary outcomes were cognitive status measured by neuropsychological examination, and functional status measured by two neurological scales and a measure of activities of daily living (ADL). Secondary measures included sleepiness, sleep quality, fatigue, and mood. Tests were performed at baseline and after the four-week intervention period.

resultsWe randomly assigned 20 patients to the CPAP group and 16 patients to the control group. The average CPAP compliance was 2.5 hours per night. Patients in the CPAP group showed significantly greater improvement in the cognitive domains of attention and executive functioning than the control group. CPAP compliance was associated with greater improvement in cognitive functioning. CPAP did not result in measurable improvement on measures of neurological status or ADL, or on any of the secondary measures.

conclusionsCPAP treatment improves cognitive functioning of stroke patients with OSA. COMMENTARY: A commentary on this article appears in this issue on page 467.

Indexed as

Activities of Daily LivingContinuous Positive Airway PressureStroke RehabilitationAdultAgedCognitionCognition DisordersFemaleHumansMaleMiddle AgedPolysomnographySleep Apnea, ObstructiveStrokeTreatment Outcomecognitive statusCPAPfunctional statusobstructive sleep apneastroke

Identifiers

PMID26888587
PMCPMC4795280

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.