ArticleScientific reports2016
Population structure and minimum core genome typing of Legionella pneumophila.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
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- Legionnaires' Disease in China Caused byMicroorganisms · 2023Article
- Legionella pneumophila Risk from Cooling Tower Systems in China.Applied and environmental microbiology · 2022Article
- Genomic characterization and assessment of pathogenic potential ofFrontiers in microbiology · 2022Article
- Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing.Nature communications · 2021Article
- Development of a Multiplex-PCR Serotyping Assay for Characterizing Legionella pneumophila Serogroups Based on the Diversity of Lipopolysaccharide Biosynthetic Loci.Journal of clinical microbiology · 2021Article
- A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera.Journal of bacteriology · 2020Article
- A novel taxon selection method, aimed at minimizing recombination, clarifies the discovery of a new sub-population ofEvolutionary applications · 2020Article
- Genomic Epidemiology of an Outbreak ofInfection and drug resistance · 2020Article
- Comparison of Whole-Genome Sequences of Legionella pneumophila in Tap Water and in Clinical Strains, Flint, Michigan, USA, 2016.Emerging infectious diseases · 2019Article
- Spatial structuring of a Legionella pneumophila population within the water system of a large occupational building.Microbial genomics · 2018Article
- Population structure of Environmental and Clinical Legionella pneumophila isolates in Catalonia.Scientific reports · 2018Article
- Comparative genome analysis reveals a complex population structure of Legionella pneumophila subspecies.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the trace.Frontiers of medicine · 2018Review
- Article
- Genomic heterogeneity differentiates clinical and environmental subgroups of Legionella pneumophila sequence type 1.PloS one · 2018Article
- Multiplex polymerase chain reaction of genetic markers for detection of potentially pathogenic environmentalThe Indian journal of medical research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionella pneumophila is an important human pathogen causing Legionnaires' disease. In this study, whole genome sequencing (WGS) was used to study the characteristics and population structure of L. pneumophila strains. We sequenced and compared 53 isolates of L. pneumophila covering different serogroups and sequence-based typing (SBT) types (STs). We found that 1,896 single-copy orthologous genes were shared by all isolates and were defined as the minimum core genome (MCG) of L. pneumophila. A total of 323,224 single-nucleotide polymorphisms (SNPs) were identified among the 53 strains. After excluding 314,059 SNPs which were likely to be results of recombination, the remaining 9,165 SNPs were referred to as MCG SNPs. Population Structure analysis based on MCG divided the 53 L. pneumophila into nine MCG groups. The within-group distances were much smaller than the between-group distances, indicating considerable divergence between MCG groups. MCG groups were also supplied by phylogenetic analysis and may be considered as robust taxonomic units within L. pneumophila. Among the nine MCG groups, eight showed high intracellular growth ability while one showed low intracellular growth ability. Furthermore, MCG typing also showed high resolution in subtyping ST1 strains. The results obtained in this study provided significant insights into the evolution, population structure and pathogenicity of L. pneumophila.
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