ArticleJournal of the American Society of Nephrology : JASN2016
Renal Function Profile in White Kidney Donors: The First 4 Decades.
Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06886087 (Prospective Study to Assess the Risks of Perinephric Fat Thickness on Adverse Renal Outcomes Post Donor Nephrectomy - ProActive Study), which is not on this map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Study to Assess the Risks of Perinephric Fat Thickness on Adverse Renal Outcomes Post Donor Nephrectomy - ProActive Study
Who cites it
55 citing papers in PubMed, 124 citations in OpenAlex.
- Perirenal Adipose Tissue may be an Important Predictor of Adverse Kidney Outcomes in Living Kidney Donors.Kidney international reports · 2026Article
- Prevalence of Obesity After Living Kidney Donation and Associated Risk Factors: Cardiovascular and Renal Implications.Journal of clinical medicine · 2025Article
- Changes in Kidney Function Following Living Donor Nephrectomy: A Retrospective, Single-Center, Descriptive Study.Cureus · 2025Article
- Relationship between new-onset proteinuria and the volume of the non-donated kidney before and after donation in living kidney donors.Clinical and experimental nephrology · 2025Observational
- Quality of Life of Donors After Living Kidney Transplantation: A Cross-Sectional Study.Life (Basel, Switzerland) · 2025Article
- Consequences of low estimated glomerular filtration rate either before or early after kidney donation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Non-Maleficence toward Young Kidney Donors: A Call for Stronger Ethical Standards and Associated Factors in Multidisciplinary Nephrology Teams.Nursing reports (Pavia, Italy) · 2024Article
- First experiences with machine learning predictions of accelerated declining eGFR slope of living kidney donors 3 years after donation.Journal of nephrology · 2024Article
- The rationale for nephron-sparing surgery in unilateral non-syndromic Wilms tumour.Pediatric nephrology (Berlin, Germany) · 2024Review
- Risk Factors for Developing Low Estimated Glomerular Filtration Rate and Albuminuria in Living Kidney Donors.Kidney medicine · 2024Article
- Quality of life, anxiety and depression symptoms in living related kidney donors: a cross‑sectional study.International urology and nephrology · 2023Article
- Development and Validation of a Hypertension Risk Calculator for Living Kidney Donors.Transplantation · 2023Article
- Article
- Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study.Yonsei medical journal · 2023Article
- External Validation of the Toulouse-Rangueil Predictive Model to Estimate Donor Renal Function After Living Donor Nephrectomy.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Long-term Medical Outcomes of Living Kidney Donors.Mayo Clinic proceedings · 2022Review
- Pre-kidney Donation Pregnancy Complications and Long-term Outcomes.Transplantation · 2022Article
- Prostanoid receptors in hyperfiltration-mediated glomerular injury: Novel agonists and antagonists reveal opposing roles for EP2 and EP4 receptors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Insufficient early renal recovery and progression to subsequent chronic kidney disease in living kidney donors.The Korean journal of internal medicine · 2022Article
- Increased risk of ischaemic heart disease after kidney donation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies reported the risk of ESRD after kidney donation, but not the renal outcomes that precede ESRD. Here, we estimated the risk of proteinuria, reduced GFR, and ESRD in 3956 white kidney donors, assessed the contribution of postdonation hypertension and diabetes to these outcomes, and developed a risk calculator. After a mean±SD follow-up of 16.6±11.9 years, 215 (6.1%) donors developed proteinuria. Men had a higher risk of proteinuria (hazard ratio [HR], 1.56; 95% confidence interval [95% CI], 1.18 to 2.05; P<0.001) as did those with higher body mass index (HR, 1.10; 95% CI, 1.06 to 1.13; P<0.001). In all, 1410 (36%) donors reached an eGFR<60 ml/min per 1.73 m(2), and 112 (2.8%) donors had either an eGFR<30 ml/min per 1.73 m(2) or ESRD (28 donors developed ESRD). An eGFR<30 ml/min per 1.73 m(2) or ESRD associated with older age (HR, 1.07; 95% CI, 1.05 to 1.09; P<0.001), higher body mass index (HR, 1.08; 95% CI, 1.04 to 1.13; P<0.001), and higher systolic BP (HR, 1.02; 95% CI, 1.00 to 1.04; P=0.01) at donation. Postdonation diabetes and hypertension associated with a fourfold higher risk of proteinuria and a >2-fold higher risk of ESRD. Models predicting proteinuria and reduced eGFR performed well (C-index 0.77-1.00). In conclusion, severe reduction in GFR and ESRD after kidney donation were uncommon and were highly associated with postdonation diabetes and hypertension. Furthermore, information available before donation may predict long-term renal outcomes in white living kidney donors.
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Registered trials
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