ArticleNature communications2016
Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Mechanochemical waves in focal adhesions during cell migration.Science advances · 2025Article
- Role of WAVE3 as an actin binding protein in the pathology of triple negative breast cancer.Cytoskeleton (Hoboken, N.J.) · 2025Review
- From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway.BMC molecular and cell biology · 2023Article
- Specialized cells that sense tissue mechanics to regulate Drosophila morphogenesis.Developmental cell · 2023Article
- Article
- Live imaging of the Drosophila ovarian niche shows spectrosome and centrosome dynamics during asymmetric germline stem cell division.Development (Cambridge, England) · 2021Article
- The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes duringOpen biology · 2021Article
- Stem cell niche organization in the Drosophila ovary requires the ECM component Perlecan.Current biology : CB · 2021Article
- The pulse of morphogenesis: actomyosin dynamics and regulation in epithelia.Development (Cambridge, England) · 2020Review
- Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis.Developmental cell · 2020Article
- Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks.PLoS genetics · 2020Article
- A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension.Nature communications · 2020Article
- Coordination of cytoskeletal dynamics and cell behaviour duringJournal of cell science · 2020Article
- The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development.PLoS genetics · 2019Article
- A biochemical network controlling basal myosin oscillation.Nature communications · 2018Article
- Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila.Cell reports · 2017Article
- Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation.Nature communications · 2017Article
- Actomyosin Pulsing in Tissue Integrity Maintenance during Morphogenesis.Trends in cell biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contractile actomyosin networks generate forces that drive tissue morphogenesis. Actomyosin contractility is controlled primarily by reversible phosphorylation of the myosin-II regulatory light chain through the action of myosin kinases and phosphatases. While the role of myosin light-chain kinase in regulating contractility during morphogenesis has been largely characterized, there is surprisingly little information on myosin light-chain phosphatase (MLCP) function in this context. Here, we use live imaging of Drosophila follicle cells combined with mathematical modelling to demonstrate that the MLCP subunit flapwing (flw) is a key regulator of basal myosin oscillations and cell contractions underlying egg chamber elongation. Flw expression decreases specifically on the basal side of follicle cells at the onset of contraction and flw controls the initiation and periodicity of basal actomyosin oscillations. Contrary to previous reports, basal F-actin pulsates similarly to myosin. Finally, we propose a quantitative model in which periodic basal actomyosin oscillations arise in a cell-autonomous fashion from intrinsic properties of motor assemblies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.