ArticleMalaria journal2016
Status of insecticide resistance in high-risk malaria provinces in Afghanistan.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review.F1000Research · 2021Pooled it
- Evolution of insecticide resistance and its mechanisms in Anopheles stephensi in the WHO Eastern Mediterranean Region.Malaria journal · 2020Pooled it
- Historical Overview of the Bionomics ofJournal of arthropod-borne diseases · 2026Review
- The origin, invasion history and resistance architecture ofbioRxiv : the preprint server for biology · 2025Article
- Preliminary monitoring of knockdown resistance (kdr) mutation in Anopheles stephensi: insights from a malarious area in Southeastern Iran.Malaria journal · 2024Article
- Ace-1 Target Site Status and Metabolic Detoxification Associated with Bendiocarb Resistance in the Field Populations of Main Malaria Vector,Journal of arthropod-borne diseases · 2023Article
- Malaria Research for Tailored Control and Elimination Strategies in the Greater Mekong Subregion.The American journal of tropical medicine and hygiene · 2022Article
- Detection and population genetic analysis of kdr L1014F variant in eastern Ethiopian Anopheles stephensi.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022Article
- Insecticide Resistance Status of Malaria Vectors in a Malarious Area, Southeast of Iran.Journal of arthropod-borne diseases · 2021Article
- Resistance Status ofJournal of arthropod-borne diseases · 2021Article
- Insecticide resistance in Anopheles stephensi in Somali Region, eastern Ethiopia.Malaria journal · 2020Article
- Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi (Diptera: Culicidae) from Afghanistan.Malaria journal · 2019Article
- Dynamics of TransgenicJournal of arthropod-borne diseases · 2017Article
- Composition ofJournal of arthropod-borne diseases · 2017Article
- Evidence of metabolic mechanisms playing a role in multiple insecticides resistance in Anopheles stephensi populations from Afghanistan.Malaria journal · 2017Review
- Epidemiology and Control of Plasmodium vivax in Afghanistan.The American journal of tropical medicine and hygiene · 2016Article
- Insecticide susceptibility of Anopheles stephensi to DDT and current insecticides in an elimination area in Iran.Parasites & vectors · 2016Article
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9 authors.
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Abstract
backgroundInsecticide resistance seriously threatens the efficacy of vector control interventions in malaria endemic countries. In Afghanistan, the status of insecticide resistance is largely unknown while distribution of long-lasting insecticidal nets has intensified in recent years. The main objective of this study was thus to measure the level of resistance to four classes of insecticides in provinces with medium to high risk of malaria transmission.
methodsAdult female mosquitoes were reared from larvae successively collected in the provinces of Nangarhar, Kunar, Badakhshan, Ghazni and Laghman from August to October 2014. WHO insecticide susceptibility tests were performed with DDT (4 %), malathion (5 %), bendiocarb (0.1 %), permethrin (0.75 %) and deltamethrin (0.05 %). In addition, the presence of kdr mutations was investigated in deltamethrin resistant and susceptible Anopheles stephensi mosquitoes collected in the eastern provinces of Nangarhar and Kunar.
resultsAnalyses of mortality rates revealed emerging resistance against all four classes of insecticides in the provinces located east and south of the Hindu Kush mountain range. Resistance is observed in both An. stephensi and Anopheles culicifacies, the two dominant malaria vectors in these provinces. Anopheles superpictus in the northern province of Badakhshan shows a different pattern of susceptibility with suspected resistance observed only for deltamethrin and bendiocarb. Genotype analysis of knock down resistance (kdr) mutations at the voltage-gated channel gene from An. stephensi mosquitoes shows the presence of the known resistant alleles L1014S and L1014F. However, a significant fraction of deltamethrin-resistant mosquitoes were homozygous for the 1014L wild type allele indicating that other mechanisms must be considered to account for the observed pyrethroid resistance.
conclusionsThis study confirms the importance of monitoring insecticide resistance for the development of an integrated vector management in Afghanistan. The validation of the kdr genotyping PCR assay applied to An. stephensi collected in Afghanistan paves the way for further studies into the mechanisms of insecticide resistance of malaria vectors in this region.
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