ArticleGenome research2016
Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies.
Article in Genome research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 112 citations in OpenAlex.
- Pan-African model explainsbioRxiv : the preprint server for biology · 2026Article
- Recovering signatures of archaic introgression using ancestral recombination graphs.bioRxiv : the preprint server for biology · 2026Article
- A structured coalescent model reveals deep ancestral structure shared by all modern humans.Nature genetics · 2025Article
- Archaic hominin admixture and its consequences for modern humans.Current opinion in genetics & development · 2025Review
- Dentition of the Mugharet El'Aliya Fossil Human Maxilla, Morocco.American journal of biological anthropology · 2025Article
- Deep history of cultural and linguistic evolution among Central African hunter-gatherers.Nature human behaviour · 2024Article
- Multiple Sources of Uncertainty Confound Inference of Historical Human Generation Times.Molecular biology and evolution · 2023Article
- Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Genetics and Material Culture Support Repeated Expansions into Paleolithic Eurasia from a Population Hub Out of Africa.Genome biology and evolution · 2022Article
- Our Tangled Family Tree: New Genomic Methods Offer Insight into the Legacy of Archaic Admixture.Genome biology and evolution · 2021Review
- The influence of evolutionary history on human health and disease.Nature reviews. Genetics · 2021Review
- The deep population history in Africa.Human molecular genetics · 2021Review
- Origins of modern human ancestry.Nature · 2021Review
- The reversal of human phylogeny: Homo left Africa as erectus, came back as sapiens sapiens.Hereditas · 2020Review
- Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph.PLoS genetics · 2020Article
- HIV-1 p24Gag adaptation to modern and archaic HLA-allele frequency differences in ethnic groups contributes to viral subtype diversification.Virus evolution · 2020Article
- Recovering signals of ghost archaic introgression in African populations.Science advances · 2020Article
- Identification of African-Specific Admixture between Modern and Archaic Humans.American journal of human genetics · 2019Article
- From a database of genomes to a forest of evolutionary trees.Nature genetics · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Comparisons of whole-genome sequences from ancient and contemporary samples have pointed to several instances of archaic admixture through interbreeding between the ancestors of modern non-Africans and now extinct hominids such as Neanderthals and Denisovans. One implication of these findings is that some adaptive features in contemporary humans may have entered the population via gene flow with archaic forms in Eurasia. Within Africa, fossil evidence suggests that anatomically modern humans (AMH) and various archaic forms coexisted for much of the last 200,000 yr; however, the absence of ancient DNA in Africa has limited our ability to make a direct comparison between archaic and modern human genomes. Here, we use statistical inference based on high coverage whole-genome data (greater than 60×) from contemporary African Pygmy hunter-gatherers as an alternative means to study the evolutionary history of the genus Homo. Using whole-genome simulations that consider demographic histories that include both isolation and gene flow with neighboring farming populations, our inference method rejects the hypothesis that the ancestors of AMH were genetically isolated in Africa, thus providing the first whole genome-level evidence of African archaic admixture. Our inferences also suggest a complex human evolutionary history in Africa, which involves at least a single admixture event from an unknown archaic population into the ancestors of AMH, likely within the last 30,000 yr.
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