ArticleBlood2016
Novel genetic predictors of venous thromboembolism risk in African Americans.
Article in Blood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.BMC medicine · 2023Pooled it
- Association of ABO polymorphisms and pancreatic Cancer/ Cardiocerebrovascular disease: a meta-analysis.BMC medical genetics · 2020Pooled it
- Risk of Cardiovascular Disease Mortality in Patients With Diagnosed Cancer and Associated Genetic and Proteomic Mechanisms: A UK Biobank-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Establishing a National Deep Vein Thrombosis Network in Ghana: findings from a prospective observational study embedded in a capacity-building initiative.BMJ public health · 2026Article
- Development of a MassARRAY Genotyping Platform and Its Clinical Application for Venous Thromboembolism Risk Assessment in Thai Patients.Medical sciences (Basel, Switzerland) · 2025Article
- Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Blood advances · 2025Article
- Predictive Factors for Pulmonary Embolism in Patients Undergoing Metabolic and Bariatric Surgery: Insights from the Latest MBSAQIP Data.Obesity surgery · 2025Article
- Pregnancy-associated venous thromboembolism in sub-Saharan Africa: a case-control study and descriptive analysis of clinical phenotypes.Research and practice in thrombosis and haemostasis · 2025Article
- Serum albumin, genetic susceptibility, and risk of venous thromboembolism.Research and practice in thrombosis and haemostasis · 2024Article
- Non-coding RNAs regulating endothelial progenitor cells for venous thrombosis: promising therapy and innovation.Stem cell research & therapy · 2024Review
- Genomewide Association Study Identifies Copy Number Variants Associated With Warfarin Dose Response and Risk of Venous Thromboembolism in African Americans.Clinical pharmacology and therapeutics · 2023Article
- The Interplay of Race/Ethnicity and Obesity on the Incidence of Venous Thromboembolism.American journal of preventive medicine · 2022Article
- Racial disparities in cancer-associated thrombosis.Blood advances · 2022Article
- Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.Genetic epidemiology · 2021Article
- Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell disease.Blood advances · 2020Article
- Discovery of novel hepatocyte eQTLs in African Americans.PLoS genetics · 2020Article
- Black Patients Experience Highest Rates of Cancer-associated Venous Thromboembolism.American journal of clinical oncology · 2020Observational
- Article
- Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.Nature genetics · 2019Article
- The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature.Nature communications · 2019Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Venous thromboembolism (VTE) is the third most common life-threatening cardiovascular condition in the United States, with African Americans (AAs) having a 30% to 60% higher incidence compared with other ethnicities. The mechanisms underlying population differences in the risk of VTE are poorly understood. We conducted the first genome-wide association study in AAs, comprising 578 subjects, followed by replication of highly significant findings in an independent cohort of 159 AA subjects. Logistic regression was used to estimate the association between genetic variants and VTE risk. Through bioinformatics analysis of the top signals, we identified expression quantitative trait loci (eQTLs) in whole blood and investigated the messenger RNA expression differences in VTE cases and controls. We identified and replicated single-nucleotide polymorphisms on chromosome 20 (rs2144940, rs2567617, and rs1998081) that increased risk of VTE by 2.3-fold (P< 6 × 10(-7)). These risk variants were found in higher frequency among populations of African descent (>20%) compared with other ethnic groups (<10%). We demonstrate that SNPs on chromosome 20 are cis-eQTLs for thrombomodulin (THBD), and the expression of THBD is lower among VTE cases compared with controls (P= 9.87 × 10(-6)). We have identified novel polymorphisms associated with increased risk of VTE in AAs. These polymorphisms are predominantly found among populations of African descent and are associated with THBD gene expression. Our findings provide new molecular insight into a mechanism regulating VTE susceptibility and identify common genetic variants that increase the risk of VTE in AAs, a population disproportionately affected by this disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.