Trial reportClinical oral investigations2016
Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients.
Trial report in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease.Scientific reports · 2021Trial
- Fumarate and fumarate hydratase: an immunometabolite regulator of inflammation and diseases.Frontiers in immunology · 2026Review
- Correlates of oral health-related quality of life in a sample of patients with rheumatoid arthritis.BMC oral health · 2025Article
- Connection between oral health and chronic diseases.MedComm · 2025Review
- Relationship Between Rheumatoid Arthritis and Periodontal Disease-Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Evaluation of salivary flow rate, pH and anti-CCP antibodies in relation to oral manifestations in patients with Rheumatoid Arthritis: A matched case-control study in Sulaimaniyah, Iraq.The Saudi dental journal · 2024Article
- Oral health and rheumatoid arthritis: a case control study.Central European journal of public health · 2024Article
- Hyposalivation and periodontal disease as oral non-articular characteristics in rheumatoid arthritis.Clinical rheumatology · 2024Observational
- Exploring the causal relationships between rheumatoid arthritis and oral phenotypes: a genetic correlation and Mendelian randomization study.Frontiers in genetics · 2024Article
- Dental Caries in Adult Patients with Rheumatoid Arthritis-A Systematic Review.Journal of clinical medicine · 2023Review
- The systemic oral health connection: Biofilms.Medicine · 2022Review
- Oral health-related quality of life and dental caries in rheumatoid arthritis patients: a cross-sectional observational study.Journal of medicine and life · 2022Observational
- Severe Periodontitis Is a Major Contributory Factor to Unmet Dental Healthcare Needs among Rheumatoid Arthritis Patients in Hong Kong.International journal of dentistry · 2022Article
- Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases.Diagnostics (Basel, Switzerland) · 2021Review
- Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis.Scientific reports · 2021Observational
- Dietary fatty acids and the time elapsed from their intake are related to their composition in rat submandibular gland and salivary flow rates.Clinical oral investigations · 2020Article
- Salivary Gland Dysfunction, Protein Glycooxidation and Nitrosative Stress in Children with Chronic Kidney Disease.Journal of clinical medicine · 2020Article
- Salivary Biomarkers and Oral Microbial Load in Relation to the Dental Status of Adults with Cystic Fibrosis.Microorganisms · 2019Article
- Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI.The Korean journal of internal medicine · 2019Article
- Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats.PloS one · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease. MATERIAL AND
methodsA prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, clinical attachment loss, bleeding index, plaque index, and the DMFT index to assess periodontal and dental alterations. Sialometric measurements were also made to determine resting, stimulated, and parotid salivary flow.
resultsThe patients with RA had greater periodontal pocket depths (with moderate depths in most cases), as well as greater attachment loss and more bacterial plaque. The resting whole saliva and stimulated parotid saliva rates were also clearly decreased in the RA group compared with the controls.
conclusionsPatients with RA are more likely to present periodontal disease, poorer oral hygiene manifesting as an increased accumulation of bacterial plaque, and decreased salivary flow rates. CLINICAL RELEVANCE: Vulnerability to periodontitis is confirmed in one of the largest samples ever studied of patients with rheumatoid arthritis (RA). Also, there is evidence of hyposialia (decrease in salivary rate) in RA patients without Sjögren's syndrome.
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Registered trials
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