ArticleBMJ (Clinical research ed.)2016
Publication and reporting of clinical trial results: cross sectional analysis across academic medical centers.
Article in BMJ (Clinical research ed.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 8 syntheses or guidelines pooled it, 239 citations in OpenAlex.
- Diagnostic Performance of Machine Learning for Systemic Lupus Erythematosus: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Time to publication for results of clinical trials.The Cochrane database of systematic reviews · 2024Pooled it
- Assessing the magnitude of reporting bias in trials of homeopathy: a cross-sectional study and meta-analysis.BMJ evidence-based medicine · 2022Pooled it
- Proportion of Women and Reporting of Outcomes by Sex in Clinical Trials for Alzheimer Disease: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- The Current Landscape of Clinical Studies Focusing on Thyroid Cancer: A Comprehensive Analysis of Study Characteristics and Their Publication Status.Frontiers in endocrinology · 2020Pooled it
- Registration of published randomized trials: a systematic review and meta-analysis.BMC medicine · 2018Pooled it
- Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials.BMJ (Clinical research ed.) · 2017Pooled it
- A systematic review of the processes used to link clinical trial registrations to their published results.Systematic reviews · 2017Pooled it
- Dissemination of trial results to study participants in Cambodia, Ethiopia and Pakistan: a qualitative study.BMJ open · 2026Trial
- Induction of Efficacy Expectancies in an Ambulatory Smartphone-Based Digital Placebo Mental Health Intervention: Randomized Controlled Trial.JMIR mHealth and uHealth · 2021Trial
- The trials and tribulations of conducting an m-health pilot randomized controlled trial to improve oral cancer therapy adherence: recommendations for future multisite, non-drug clinical trials.BMC research notes · 2019Trial
- Review
- Discontinuation and non-publication of atrial fibrillation clinical trials: A retrospective analysis of 538 trials.International journal of cardiology. Heart & vasculature · 2026Article
- Non-Publication of Interventional Studies for Uveal Melanoma.Ocular oncology and pathology · 2026Article
- Consistency Between Clinical Trial Registry Entries and Journal Publications in Transfusion Medicine: An Observational Study.Journal of clinical medicine · 2026Article
- Article
- Determinants of publication likelihood and timeliness for clinical studies.Journal of clinical and translational science · 2026Article
- Towards monitoring of global health research: an exploratory analysis of transparency and stakeholder engagement.BMJ open · 2025Article
- Article
- SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials.BMJ (Clinical research ed.) · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo determine rates of publication and reporting of results within two years for all completed clinical trials registered in ClinicalTrials.gov across leading academic medical centers in the United States.
designCross sectional analysis.
settingAcademic medical centers in the United States.
participantsAcademic medical centers with 40 or more completed interventional trials registered on ClinicalTrials.gov.
methodsUsing the Aggregate Analysis of ClinicalTrials.gov database and manual review, we identified all interventional clinical trials registered on ClinicalTrials.gov with a primary completion date between October 2007 and September 2010 and with a lead investigator affiliated with an academic medical center.
main outcome measuresThe proportion of trials that disseminated results, defined as publication or reporting of results on ClinicalTrials.gov, overall and within 24 months of study completion.
resultsWe identified 4347 interventional clinical trials across 51 academic medical centers. Among the trials, 1005 (23%) enrolled more than 100 patients, 1216 (28%) were double blind, and 2169 (50%) were phase II through IV. Overall, academic medical centers disseminated results for 2892 (66%) trials, with 1560 (35.9%) achieving this within 24 months of study completion. The proportion of clinical trials with results disseminated within 24 months of study completion ranged from 16.2% (6/37) to 55.3% (57/103) across academic medical centers. The proportion of clinical trials published within 24 months of study completion ranged from 10.8% (4/37) to 40.3% (31/77) across academic medical centers, whereas results reporting on ClinicalTrials.gov ranged from 1.6% (2/122) to 40.7% (72/177).
conclusionsDespite the ethical mandate and expressed values and mission of academic institutions, there is poor performance and noticeable variation in the dissemination of clinical trial results across leading academic medical centers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.