ArticleeLife2016
Cascade of neural processing orchestrates cognitive control in human frontal cortex.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Insights into the neural mechanisms supporting cognitive stability and flexibility from human intracranial electroencephalography.Neuroscience and biobehavioral reviews · 2026Review
- Frontotemporal network interactions causally support rapid concreteness judgments during reading.PLoS biology · 2026Article
- Theta-Alpha Dysregulation reveals impaired endogenous cognitive control in adolescent Obsessive-Compulsive disorder.NeuroImage. Clinical · 2026Article
- Virtual Reality-Based Cognitive and Physical Interventions in Cognitive Impairment: A Network Meta-Analysis of Immersion Level Effects.Behavioral sciences (Basel, Switzerland) · 2025Review
- Neural dynamics of proactive and reactive cognitive control in medial and lateral prefrontal cortex.iScience · 2025Article
- Optimal level of human intracranial theta activity for behavioral switching in the subthalamo-medio-prefrontal circuit.Nature communications · 2024Article
- Uncovering the fast, directional signal flow through the human temporal pole during semantic processing.Scientific reports · 2023Article
- Functional lateralization of the medial temporal lobe in novel associative processing during creativity evaluation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cross-task specificity and within-task invariance of cognitive control processes.Cell reports · 2023Article
- The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective.Frontiers in neuroanatomy · 2023Article
- Prefrontal network engagement by deep brain stimulation in limbic hubs.Frontiers in human neuroscience · 2023Article
- Learning induces coordinated neuronal plasticity of metabolic demands and functional brain networks.Communications biology · 2022Article
- Article
- Neural Interactions Underlying Visuomotor Associations in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Widespread temporal coding of cognitive control in the human prefrontal cortex.Nature neuroscience · 2019Article
- Rapid and specific processing of person-related information in human anterior temporal lobe.Communications biology · 2019Article
- Temporal Dynamics of Human Frontal and Cingulate Neural Activity During Conflict and Cognitive Control.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Domain-General and Domain-Specific Patterns of Activity Supporting Metacognition in Human Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Effect of Threat on Right dlPFC Activity during Behavioral Pattern Separation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A Neural Mechanism of Social Categorization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is a critical component of cognitive control that is orchestrated by frontal cortex. The relative roles of distinct subregions within frontal cortex are poorly understood. To examine the dynamics underlying cognitive control across frontal regions, we took advantage of the spatiotemporal resolution of intracranial recordings in epilepsy patients while subjects resolved color-word conflict. We observed differential activity preceding the behavioral responses to conflict trials throughout frontal cortex; this activity was correlated with behavioral reaction times. These signals emerged first in anterior cingulate cortex (ACC) before dorsolateral prefrontal cortex (dlPFC), followed by medial frontal cortex (mFC) and then by orbitofrontal cortex (OFC). These results disassociate the frontal subregions based on their dynamics, and suggest a temporal hierarchy for cognitive control in human cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.