ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Reduced Inhibitory Control Mediates the Relationship Between Cortical Thickness in the Right Superior Frontal Gyrus and Body Mass Index.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Inhibitory control mediates the association between perinatal PM2.5 exposure and childhood obesity in children in the PROGRESS cohort, Mexico City.Communications medicine · 2026Article
- Abnormal resting-state effective connectivity of triple network predicts smoking motivations among males.Frontiers in psychiatry · 2025Article
- A review of brain structural and functional changes using MRI technology in patients who received bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025Review
- Article
- Functional decoding and meta-analytic connectivity modeling in thyroid-associated ophthalmopathy.Heliyon · 2024Article
- Food stimuli decrease activation in regions of the prefrontal cortex related to executive function: an fNIRS study.Eating and weight disorders : EWD · 2023Article
- Challenging inhibitory control with high- and low-calorie food: A behavioural and TMS study.Frontiers in nutrition · 2023Article
- Clarifying the synergistic effects of emotion dysregulation and inhibitory control on physical aggression.Human brain mapping · 2022Article
- Aberrant impulse control circuitry in obesity.Molecular psychiatry · 2022Article
- Alteration of regional heterogeneity and functional connectivity for obese undergraduates: evidence from resting-state fMRI.Brain imaging and behavior · 2022Article
- Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers.Frontiers in psychiatry · 2022Article
- Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood.Developmental cognitive neuroscience · 2019Article
- A hypothesis linking the energy demand of the brain to obesity risk.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Decreased Task-Related HRV Is Associated With Inhibitory Dysfunction Through Functional Inter-Region Connectivity of PFC in Major Depressive Disorder.Frontiers in psychiatry · 2019Article
- Altered cortical thickness and attentional deficits in adolescent girls and women with bulimia nervosa.Journal of psychiatry & neuroscience : JPN · 2018Article
- Independent and Differential Effects of Obesity and Hypertension on Cognitive and Functional Abilities.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Unhealthy eating behaviors often develop in the setting of inadequate inhibitory control, a function broadly ascribed to the prefrontal cortex (PFC). Regulation of inhibitory control by the PFC and its anatomical components and their contribution to increasing body mass index (BMI) are poorly understood. To study the role of PFC in the regulation of inhibitory control and body weight, we examined measures of cortical thickness in PFC sub-regions, inhibitory control (color-word interference task (CWIT)), and BMI in 91 healthy volunteers. We tested the predictive effect of PFC sub-regional cortical thickness on BMI and mediation by inhibitory control measured with CWIT. Measures of depression (BDI-II), anxiety (STAI-T) and trauma-related symptoms (TSC-40) were collected; the disinhibition scale of the three-factor eating questionnaire (TFEQ) was used to assess disinhibited eating. We then tested the relationship between BD-II, STAI-T, TSC-40, TFEQ, CWIT, and BMI with correlation analyses. Right superior frontal gyrus cortical thickness significantly predicted BMI (β=-0.91; t=-3.2; p=0.002). Mediation analysis showed a significant indirect effect of cortical thickness on BMI mediated by inhibitory control (95% CI=-6.1, -0.67). BMI was unrelated to BDI-II, STAI-T, TSC-40, or TFEQ scores. We found an inverse relationship between cortical thickness in the right-superior frontal gyrus and BMI, which was fully mediated by inhibitory control neurocognitive performance. Our results suggest possible targets for neuromodulation in obesity (ie superior frontal gyrus) and a quantifiable mediator of their effects (ie inhibitory control).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.