ArticleThe Journal of biological chemistry2016
Importin α1 Mediates Yorkie Nuclear Import via an N-terminal Non-canonical Nuclear Localization Signal.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy.Journal of nanobiotechnology · 2025Article
- M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import.iScience · 2025Article
- A feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration.Nature communications · 2025Article
- WW domains form a folded type of nuclear localization signal to guide YAP1 nuclear import.The Journal of cell biology · 2024Article
- Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development.Cellular oncology (Dordrecht, Netherlands) · 2024Article
- SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors.Signal transduction and targeted therapy · 2024Article
- The role of the FSGS disease gene product and nuclear pore protein NUP205 in regulating nuclear localization and activity of transcriptional regulators YAP and TAZ.Human molecular genetics · 2023Article
- YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions.Cell death discovery · 2023Article
- Nuclear Import and Export of YAP and TAZ.Cancers · 2023Review
- Expression Analysis in a Dispersal-Fecundity Polyphenism Identifies Growth Regulators and Effectors.Integrative and comparative biology · 2022Article
- Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP.Nature communications · 2022Article
- On the nuclear pore complex and its emerging role in cellular mechanotransduction.APL bioengineering · 2022Review
- An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling.Journal of cell science · 2021Article
- Review
- Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View.Frontiers in cell and developmental biology · 2021Review
- Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation.Cellular and molecular life sciences : CMLS · 2020Article
- Gone Caving: Roles of the Transcriptional Regulators YAP and TAZ in Skeletal Development.Current osteoporosis reports · 2020Review
- MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.The Journal of experimental medicine · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hippo signaling pathway controls organ size by orchestrating cell proliferation and apoptosis. When the Hippo pathway was inactivated, the transcriptional co-activator Yorkie translocates into the nucleus and forms a complex with transcription factor Scalloped to promote the expression of Hippo pathway target genes. Therefore, the nuclear translocation of Yorkie is a critical step in Hippo signaling. Here, we provide evidence that the N-terminal 1-55 amino acids of Yorkie, especially Arg-15, were essential for its nuclear localization. By mass spectrometry and biochemical analyses, we found that Importin α1 can directly interact with the Yorkie N terminus and drive Yorkie into the nucleus. Further experiments show that the upstream component Hippo can inhibit Importin α1-mediated Yorkie nuclear import. Taken together, we identified a potential nuclear localization signal at the N-terminal end of Yorkie as well as a critical role for Importin α1 in Yorkie nuclear import.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.