Evidence map›Paper›PMID 26887526›Full record

ArticleAIDS care2016

A risk score to identify HIV-infected women most likely to become lost to follow-up in the postpartum period.

Angela M Bengtson, Carla J Chibwesha, Daniel Westreich, Mwangelwa Mubiana-Mbewe, Benjamin H Chi, William C Miller, Muntanga Mapani, Brian W Pence, Patrick Musonda, Jeffrey Sa Stringer and 1 more

Abstract read
In one paragraph

Article in AIDS care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Breastfeeding with HIV: An Evidence-Based Case for New Policy.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angela M Bengtsona Department of Epidemiology , University of North Carolina , Chapel Hill , NC , USA.
Carla J Chibweshab Department of Obstetrics and Gynecology , University of North Carolina , Chapel Hill , NC , USA.
Daniel Westreicha Department of Epidemiology , University of North Carolina , Chapel Hill , NC , USA.
Mwangelwa Mubiana-Mbewec Centre for Infectious Disease Research , Zambia , Africa.
Benjamin H Chib Department of Obstetrics and Gynecology , University of North Carolina , Chapel Hill , NC , USA.
William C Millera Department of Epidemiology , University of North Carolina , Chapel Hill , NC , USA.
Muntanga Mapanib Department of Obstetrics and Gynecology , University of North Carolina , Chapel Hill , NC , USA.
Brian W Pencea Department of Epidemiology , University of North Carolina , Chapel Hill , NC , USA.
Patrick Musondae Department of Public Health , University of Zambia School of Medicine , Lusaka , Zambia , Africa.
Jeffrey Sa Stringerb Department of Obstetrics and Gynecology , University of North Carolina , Chapel Hill , NC , USA.
Audrey Pettifora Department of Epidemiology , University of North Carolina , Chapel Hill , NC , USA.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Science/Technical CoreP2CHD041020 · NICHD · BROWN UNIVERSITY · PI Margot Jackson · 2016 to 2026
$7.6M
NIAID NIH HHS P30 AI050410NIAID NIH HHS T32 AI007001NICHD NIH HHS P2C HD041020NICHD NIH HHS P2C HD050924
6 · The paper itself

Abstract

Access to lifelong combination antiretroviral therapy (cART) is expanding among HIV-infected pregnant and breastfeeding women throughout sub-Saharan Africa (SSA). For this strategy to meaningfully improve maternal HIV outcomes, retention in HIV care is essential. We developed a risk score to identify women with high likelihood of loss to follow-up (LTFU) at 6 months postpartum from HIV care, using data from public health facilities in Lusaka, Zambia. LTFU was defined as not presenting for HIV care within 60 days of the last scheduled appointment. We used logistic regression to assess demographic, obstetric and HIV predictors of LTFU and to develop a simple risk score. Sensitivity and specificity were assessed at each risk score cut-point. Among 2029 pregnant women initiating cART between 2009 and 2011, 507 (25%) were LTFU by 6 months postpartum. Parity, education, employment status, WHO clinical stage, duration of cART during pregnancy and number of antenatal care visits were associated with LTFU (p-value < .10). A risk score cut-point of 11 (42nd percentile) had 85% sensitivity (95% CI 82%, 88%) and 22% specificity (95% CI 20%, 24%) to detect women LTFU and would exclude 20% of women from a retention intervention. A risk score cut-point of 18 (69th percentile) identified the 23% of women with the highest probability of LTFU and had sensitivity 32% (95% CI 28%, 36%) and specificity 80% (95% CI 78%, 82%). A risk score approach may be useful to triage a subset of women most likely to be LTFU for targeted retention interventions.

Indexed as

Antiretroviral Therapy, Highly ActiveLost to Follow-UpMothersPostpartum PeriodAdultBreast FeedingContinuity of Patient CareFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalLogistic ModelsPatient DropoutsPregnancyPrenatal CareRetrospective StudiesantiretroviralHIVloss to follow-uppostpartumpregnancy

Identifiers

PMID26887526
PMCPMC4974091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.