ArticleScientific reports2016
Ancestry variation and footprints of natural selection along the genome in Latin American populations.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Present-day Admixed Genomes Reveal Prehistoric Adaptation to Cold, Maritime Diet, and Local Pathogens in Patagonia.Genome biology and evolution · 2026Article
- Characterizing substructure via mixture modeling in large-scale genetic summary statistics.American journal of human genetics · 2025Article
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Characterizing substructure via mixture modeling in large-scale genetic summary statistics.bioRxiv : the preprint server for biology · 2024Article
- Joint multi-ancestry and admixed GWAS reveals the complex genetics behind human cranial vault shape.Nature communications · 2023Review
- Inferring multi-locus selection in admixed populations.PLoS genetics · 2023Article
- Disentangling Signatures of Selection Before and After European Colonization in Latin Americans.Molecular biology and evolution · 2022Article
- The genomic signatures of natural selection in admixed human populations.American journal of human genetics · 2022Article
- Continental-scale genomic analysis suggests shared post-admixture adaptation in the Americas.Human molecular genetics · 2021Article
- New insights into human immunity from ancient genomics.Current opinion in immunology · 2021Review
- Admixture with indigenous people helps local adaptation: admixture-enabled selection in Polynesians.BMC ecology and evolution · 2021Article
- Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.Nature genetics · 2021Article
- Genetic variability in COVID-19-related genes in the Brazilian population.Human genome variation · 2021Article
- Exploring a Region on Chromosome 8p23.1 Displaying Positive Selection Signals in Brazilian Admixed Populations: Additional Insights Into Predisposition to Obesity and Related Disorders.Frontiers in genetics · 2021Article
- Postadmixture Selection on Chileans Targets Haplotype Involved in Pigmentation, Thermogenesis and Immune Defense against Pathogens.Genome biology and evolution · 2020Article
- Dating admixture events is unsolved problem in multi-way admixed populations.Briefings in bioinformatics · 2020Article
- Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia.World journal of diabetes · 2019Article
- A comprehensive survey of models for dissecting local ancestry deconvolution in human genome.Briefings in bioinformatics · 2019Article
- Distribution of local ancestry and evidence of adaptation in admixed populations.Scientific reports · 2019Article
- Adaptation of human skin color in various populations.Hereditas · 2018Review
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4 authors.
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Abstract
Latin American populations stem from the admixture of Europeans, Africans and Native Americans, which started over 400 years ago and had lasted for several centuries. Extreme deviation over the genome-wide average in ancestry estimations at certain genomic locations could reflect recent natural selection. We evaluated the distribution of ancestry estimations using 678 genome-wide microsatellite markers in 249 individuals from 13 admixed populations across Latin America. We found significant deviations in ancestry estimations including three locations with more than 3.5 times standard deviations from the genome-wide average: an excess of European ancestry at 1p36 and 14q32, and an excess of African ancestry at 6p22. Using simulations, we could show that at least the deviation at 6p22 was unlikely to result from genetic drift alone. By applying different linguistic groups as well as the most likely ancestral Native American populations as the ancestry, we showed that the choice of Native American ancestry could affect the local ancestry estimation. However, the signal at 6p22 consistently appeared in most of the analyses using various ancestral groups. This study provided important insights for recent natural selection in the context of the unique history of the New World and implications for disease mapping.
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