Evidence map›Paper›PMID 26887327›Full record

Trial reportPhysiological reports2016

Exercise training improves vascular function in adolescents with type 2 diabetes.

Louise H Naylor, Elizabeth A Davis, Rachelle J Kalic, Niru Paramalingam, Mary B Abraham, Timothy W Jones, Daniel J Green

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 9 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 9 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Louise H NaylorSchool of Sport Science, Exercise & Health, The University of Western Australia, Crawley, Australia Louise.Naylor@uwa.edu.au.
Elizabeth A DavisSchool of Paediatric and Child Health, The University of Western Australia, Crawley, Australia Telethon Kids Institute, The University of Western Australia, Subiaco, Australia Department of Endocrinology and Diabetes, Princess Margaret Hospital, Subiaco, Australia.
Rachelle J KalicTelethon Kids Institute, The University of Western Australia, Subiaco, Australia Department of Endocrinology and Diabetes, Princess Margaret Hospital, Subiaco, Australia.
Niru ParamalingamTelethon Kids Institute, The University of Western Australia, Subiaco, Australia Department of Endocrinology and Diabetes, Princess Margaret Hospital, Subiaco, Australia.
Mary B AbrahamSchool of Paediatric and Child Health, The University of Western Australia, Crawley, Australia Department of Endocrinology and Diabetes, Princess Margaret Hospital, Subiaco, Australia.
Timothy W JonesSchool of Paediatric and Child Health, The University of Western Australia, Crawley, Australia Telethon Kids Institute, The University of Western Australia, Subiaco, Australia Department of Endocrinology and Diabetes, Princess Margaret Hospital, Subiaco, Australia.
Daniel J GreenSchool of Sport Science, Exercise & Health, The University of Western Australia, Crawley, Australia Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
University of Western Australia · AUDiabetes Australia · AUThe Kids Research Institute Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of exercise training on vascular health in adolescents with type 2 diabetes has not been previously studied. We hypothesized that exercise training would improve micro- and macrovascular health in adolescents with type 2 diabetes. Thirteen adolescents (13-21 years, 10F) with type 2 diabetes were recruited from Princess Margaret Hospital. Participants were randomized to receive either an exercise program along with standard clinical care (n = 8) or standard care alone (n = 5). Those in the intervention group received 12 weeks of gym-based, personalized, and supervised exercise training. Those in the control group were instructed to maintain usual activity levels. Assessments were conducted at baseline and following week 12. The exercise group was also studied 12 weeks following the conclusion of their program. Assessments consisted of conduit artery endothelial function (flow-mediated dilation, FMD) and microvascular function (cutaneous laser Doppler). Secondary outcomes included body composition (dual-energy X-ray absorptiometry, DXA), glycemic control (whole body insulin sensitivity, M) assessed using the euglycemic-hyperinsulinemic clamp protocol, cardiorespiratory fitness (V˙O2peak), and muscular strength (1RM). Exercise training increased FMD (P < 0.05), microvascular function (P < 0.05), total lean mass (P < 0.05), and muscle strength (P < 0.001). There were no changes in cardiorespiratory fitness, body weight, BMI, or M. In the control group, body weight (P < 0.01), BMI (P < 0.01), and total fat mass (P < 0.05) increased. At week 24, improvements in vascular function were reversed. This study indicates that exercise training can improve both conduit and microvascular endothelial function and health, independent of changes in insulin sensitivity in adolescents with type 2 diabetes.

Indexed as

AdolescentBody CompositionDiabetes Mellitus, Type 2Endothelium, VascularExercise TherapyFemaleGlucose Clamp TechniqueHumansInsulin ResistanceLaser-Doppler FlowmetryMaleMicrocirculationMicrodialysisMuscle StrengthPhysical FitnessVasodilationDiabetesexercise trainingvascular endothelium

Identifiers

PMID26887327
PMCPMC4759041
OpenAlexW2287626525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.