ArticleBMC complementary and alternative medicine2016
Rg3-enriched ginseng extract ameliorates scopolamine-induced learning deficits in mice.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Compound K-enriched Korean red ginseng prevents lung cancer progression by targeting cancer cells and fibroblasts.Journal of ginseng research · 2025Article
- Harvesting Health: Phytochemicals in Cognitive Impairment Therapy.Central nervous system agents in medicinal chemistry · 2025Review
- Review
- Panaxcerol D fromJournal of ginseng research · 2024Article
- Active Compounds ofPharmaceuticals (Basel, Switzerland) · 2023Review
- The Neuroprotective Effects ofInternational journal of molecular sciences · 2023Article
- The Untapped Potential of Ginsenosides and American Ginseng Berry in Promoting Mental Health via the Gut-Brain Axis.Nutrients · 2022Review
- Antioxidant-based neuroprotective effect of dimethylsulfoxide against induced traumatic brain injury in a rats model.Frontiers in pharmacology · 2022Article
- Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Neuroprotective Effect and Antioxidant Potency of Fermented Cultured Wild Ginseng Root Extracts ofMolecules (Basel, Switzerland) · 2021Article
- Effects of Ginseng on Neurological Disorders.Frontiers in cellular neuroscience · 2020Review
- Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice.Experimental and therapeutic medicine · 2019Article
- Ginsenosides Rg5 and Rk1 Enriched Cultured Wild Ginseng Root Extract Bioconversion ofNutrients · 2019Article
- Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases.Journal of ginseng research · 2019Review
- Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study.Oncotarget · 2018Review
- Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model.Laboratory animal research · 2018Article
- Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs.Frontiers in aging neuroscience · 2018Review
- Protective Effects of Red Ginseng Oil against AβInternational journal of molecular sciences · 2017Article
- Antidepressant-like effects of ginsenoside Rg3 in mice via activation of the hippocampal BDNF signaling cascade.Journal of natural medicines · 2017Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGinseng (Panax ginseng C.A. Meyer) has been used as a traditional herb in the treatment of many medical disorders. Ginsenosides, which are triterpene derivatives that contain sugar moieties, are the main pharmacological ingredients in ginseng. This study was designed to investigate the effect of ginsenoside Rg3-enriched ginseng extract (Rg3GE) on scopolamine-induced memory impairment in mice.
methodsRg3GE (50 and 100 mg/kg) were administered to C57BL/6 mice by oral gavage for 14 days (days 1-14). Memory impairment was induced by scopolamine (1 mg/kg, intraperitoneal injection) for 6 days (days 914). The Morris water maze test was used to assess hippocampus-dependent spatial memory. The effects of scopolamine with or without Rg3GE on acetylcholinesterase and nuclear factor-κB (NF-κB) in the hippocampus were also examined.
resultsMice with scopolamine treatment alone showed impairments in the acquisition and retention of spatial memory. Mice that received Rg3GE and scopolamine showed no scopolamine-induced impairment in the acquisition of spatial memory. Oral administration of Rg3GE suppressed the scopolamine-mediated increase in acetylcholinesterase activity and stimulation of the NF-κB pathway (i.e., phosphorylation of p65) in the hippocampus.
conclusionThese findings suggest that Rg3GE may stabilize scopolamine-induced memory deficits through the inhibition of acetylcholinesterase activity and NF-κB signaling in the hippocampus.
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