Trial reportScientific reports2016
Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Functional in-vitro evaluation of the non-specific effects of BCG vaccination in a randomised controlled clinical study.Scientific reports · 2022Trial
- Molecular basis and therapeutic potential of sortase A inhibitors as new antibiotics against MDR pathogens.Open biology · 2026Review
- Dynamic tethering of M protein drives pathological inflammation during group A Streptococcus infections.PLoS pathogens · 2026Article
- Real-time characterisation of microbe-induced inflammation using a novel zebrafish larval corneal injury and infection model.Communications biology · 2026Article
- <italic>Streptococcus pyogenes</italic> Infection and CD4Journal of innate immunity · 2026Article
- The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.European journal of medical research · 2024Article
- [The Relationship of Dysbiosis of Duodenal Microbiome and Functional Dyspepsia].The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- Associations among the Duodenal Ecosystem, Gut Microbiota, and Nutrient Intake in Functional Dyspepsia.Gut and liver · 2024Article
- The predictive value of heparin-binding protein for bacterial infections in patients with severe polytrauma.PloS one · 2024Article
- AZU1: a new promising marker for infection in orthopedic and trauma patients?EXCLI journal · 2024Article
- Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes.Journal of biomedical science · 2023Article
- TLR4-mediated release of heparin-binding protein in human airways: a co-stimulatory role for IL-26.Frontiers in immunology · 2023Article
- Hypoxia Increases the Potential for Neutrophil-mediated Endothelial Damage in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2022Article
- [Duodenal Microbiome and Its Clinical Implications in Functional Dyspepsia].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Review
- Accuracy of heparin-binding protein for the diagnosis of nosocomial meningitis and ventriculitis.Critical care (London, England) · 2022Observational
- Resistin Associated With Cytokines and Endothelial Cell Adhesion Molecules Is Related to Worse Outcome in COVID-19.Frontiers in immunology · 2022Article
- Heparin-binding protein-enhanced quick SOFA score improves mortality prediction in sepsis patients.Frontiers in medicine · 2022Article
- COVID-19-Associated Acute Brain Dysfunction Related to Sepsis.Journal of clinical medicine research · 2021Review
- The Relationship Between Functional Dyspepsia, PPI Therapy, and the Gastric Microbiome.Kansas journal of medicine · 2021Review
- Resistin, a Novel Host Defense Peptide of Innate Immunity.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils are critical for the control of bacterial infections, but they may also contribute to disease pathology. Here we explore neutrophil responses, in particular the release of sepsis-associated factors heparin-binding protein (HBP) and resistin in relation to specific bacterial stimuli and sepsis of varying aetiology. Analyses of HBP and resistin in plasma of septic patients revealed elevated levels as compared to non-infected critically ill patients. HBP and resistin correlated significantly in septic patients, with the strongest association seen in group A streptococcal (GAS) cases. In vitro stimulation of human neutrophils revealed that fixed streptococcal strains induced significantly higher release of HBP and resistin, as compared to Staphylococcus aureus or Escherichia coli. Similarly, neutrophils stimulated with the streptococcal M1-protein showed a significant increase in co-localization of HBP and resistin positive granules as well as exocytosis of these factors, as compared to LPS. Using a GAS strain deficient in M1-protein expression had negligible effect on neutrophil activation, while a strain deficient in the stand-alone regulator MsmR was significantly less stimulatory as compared to its wild type strain. Taken together, the findings suggest that the streptococcal activation of neutrophils is multifactorial and involves, but is not limited to, proteins encoded by the FCT-locus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.