ArticleMammalian genome : official journal of the International Mammalian Genome Society2016
A large insertion in intron 2 of the TYRP1 gene associated with American Palomino phenotype in American mink.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Coat color inheritance in American mink.BMC genomics · 2023Article
- The Genetic Diversity of Mink (Animals : an open access journal from MDPI · 2023Article
- The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics.Animals : an open access journal from MDPI · 2022Article
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- Identification of mutant gene for Black crystal coat and non-allelic gene interactions in Neogale vison.Scientific reports · 2022Article
- A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius).PloS one · 2022Article
- Article
- Analysis ofAnimals : an open access journal from MDPI · 2021Article
- Article
- Genome analysis identifies the mutant genes for common industrial Silverblue and Hedlund white coat colours in American mink.Scientific reports · 2019Article
- Article
- SNP markers associated with body size and pelt length in American mink (Neovison vison).BMC genetics · 2018Article
- Comparative Transcriptome Analysis of Mink (Neovison vison) Skin Reveals the Key Genes Involved in the Melanogenesis of Black and White Coat Colour.Scientific reports · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
A number of American mink phenotypes display a range of brownish colours. One of these phenotypes, namely American Palomino (b (P) b (P) ) (AP) has been found to be associated with the tyrosinase-related protein 1 (TYRP1) gene by genotyping microsatellite markers in one sire family. Trials for amplifying the genomic DNA and cDNA at the beginning of intron 2 of AP TYRP1 revealed the presence of a large insertion of approximately eight kb. The insertion most likely disrupts different elements necessary for the splicing of intron 2 of the TYRP1 gene. In AP RNAseq data indicate, however, the presence of the wild-type (wt) transcript at very low levels and Western blot reveals three products when using an antibody raised against middle part of the TYRP1 protein. One individual from another brown mink phenotype-commercially named Dawn-was also investigated at the molecular level by long-range PCR and the same size insertion appears to be present. By this we suggest that certain modifiers of TYRP1 would induce different brown colour degradation, which results in at least two different phases of brown.
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