Evidence map›Paper›PMID 26886917›Full record

ArticlePloS one2016

Whole-Body Vibration Partially Reverses Aging-Induced Increases in Visceral Adiposity and Hepatic Lipid Storage in Mice.

Aaffien C Reijne, Jolita Ciapaite, Theo H van Dijk, Rick Havinga, Eddy A van der Zee, Albert K Groen, Dirk-Jan Reijngoud, Barbara M Bakker, Gertjan van Dijk

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
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  10. WHOLE BODY VIBRATION IMPROVES ATTENTION AND MOTOR PERFORMANCE IN MICE DEPENDING ON THE DURATION OF THE WHOLE-BODY VIBRATION SESSION.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017
    Article
  11. Beneficial Effects of Whole Body Vibration on Brain Functions in Mice and Humans.Dose-response : a publication of International Hormesis Society
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aaffien C ReijneGroningen Institute for Evolutionary Life Sciences, Neurobiology, Unit of Behavioral Neurosciences, University of Groningen, Nijenborgh 7, NL-9747AG Groningen, The Netherlands.
Jolita CiapaiteDepartment of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.
Theo H van DijkDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9700RB Groningen, The Netherlands.
Rick HavingaDepartment of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.
Eddy A van der ZeeGroningen Institute for Evolutionary Life Sciences, Neurobiology, Unit of Molecular Neurobiology, University of Groningen, Nijenborgh 7, NL-9747AG Groningen, The Netherlands.
Albert K GroenDepartment of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.
Dirk-Jan ReijngoudDepartment of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.
Barbara M BakkerDepartment of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, NL-9713GZ Groningen, The Netherlands.
Gertjan van DijkGroningen Institute for Evolutionary Life Sciences, Neurobiology, Unit of Behavioral Neurosciences, University of Groningen, Nijenborgh 7, NL-9747AG Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At old age, humans generally have declining muscle mass and increased fat deposition, which can increase the risk of developing cardiometabolic diseases. While regular physical activity postpones these age-related derangements, this is not always possible in the elderly because of disabilities or risk of injury. Whole-body vibration (WBV) training may be considered as an alternative to physical activity particularly in the frail population. To explore this possibility, we characterized whole-body and organ-specific metabolic processes in 6-month and 25-month old mice, over a period of 14 weeks of WBV versus sham training. WBV training tended to increase blood glucose turnover rates and stimulated hepatic glycogen utilization during fasting irrespective of age. WBV was effective in reducing white fat mass and hepatic triglyceride content only in old but not in young mice and these reductions were related to upregulation of hepatic mitochondrial uncoupling of metabolism (assessed by high-resolution respirometry) and increased expression of uncoupling protein 2. Because these changes occurred independent of changes in food intake and whole-body metabolic rate (assessed by indirect calorimetry), the liver-specific effects of WBV may be a primary mechanism to improve metabolic health during aging, rather than that it is a consequence of alterations in energy balance.

Indexed as

AdiposityLipid MetabolismVibrationAgingAnimalsBlood GlucoseBody CompositionCalorimetry, IndirectCarbohydrate MetabolismEnergy MetabolismLiverMaleMice, Inbred C57BLMitochondria, LiverMuscle, SkeletalVisceraBlood Glucose

Identifiers

PMID26886917
PMCPMC4757540
OpenAlexW2282101465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.