ArticleJournal of materials science. Materials in medicine2016
Is dialdehyde starch a valuable cross-linking agent for collagen/elastin based materials?
Article in Journal of materials science. Materials in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- 3D printed fish scale collagen/RSC advances · 2026Article
- Dialdehyde Alginate as a Crosslinker for Chitosan/Starch Films: Toward Biocompatible and Antioxidant Wound Dressing Materials.International journal of molecular sciences · 2026Article
- Dialdehyde Starch Cross-Linked Collagen with Heparin Conjugation: Characterization and Feasibility Study for Osteochondral Tissue Repair.Gels (Basel, Switzerland) · 2025Article
- Design and Evaluation of a Crosslinked Chitosan-Based Scaffold Containing Hyaluronic Acid for Articular Cartilage Reconstruction.Molecules (Basel, Switzerland) · 2025Article
- Vegetative and microbial proteins for bioplastics applications - a review in the indian context.RSC advances · 2025Review
- Cross-Linking Agents in Three-Component Materials Dedicated to Biomedical Applications: A Review.Polymers · 2024Review
- Gelatin-Sodium Alginate Hydrogels Cross-Linked by Squaric Acid and Dialdehyde Starch as a Potential Bio-Ink.Polymers · 2024Article
- Cross-Linking Methods of the Silk Protein Hydrogel in Oral and Craniomaxillofacial Tissue Regeneration.Tissue engineering and regenerative medicine · 2024Review
- Dialdehyde Starch as a Cross-Linking Agent Modifying Fish Collagen Film Properties.Materials (Basel, Switzerland) · 2024Article
- Modification of the Human Amniotic Membrane Using Different Cross-Linking Agents as a Promising Tool for Regenerative Medicine.Materials (Basel, Switzerland) · 2023Article
- Alginate Conjugation Increases Toughness in Auricular Chondrocyte Seeded Collagen Hydrogels.Bioengineering (Basel, Switzerland) · 2023Article
- Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?Pharmaceutics · 2023Review
- Extraction and characterization of collagen from the skin of Amazonian freshwater fish pirarucu.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Review
- Chitosan-Gelatin Films Cross-Linked with Dialdehyde Cellulose Nanocrystals as Potential Materials for Wound Dressings.International journal of molecular sciences · 2022Article
- Options to Improve the Mechanical Properties of Protein-Based Materials.Molecules (Basel, Switzerland) · 2022Review
- Article
- The Characterization of Scaffolds Based on Dialdehyde Chitosan/Hyaluronic Acid.Materials (Basel, Switzerland) · 2021Article
- Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?International journal of molecular sciences · 2021Article
- How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?-Blending and Cross-Linking of Silk Fibroin-A Review.Materials (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen and elastin are the main structural proteins in mammal bodies. They provide mechanical support, strength, and elasticity to various organs and tissues, e.g. skin, tendons, arteries, and bones. They are readily available, biodegradable, biocompatible and they stimulate cell growth. The physicochemical properties of collagen and elastin-based materials can be modified by cross-linking. Glutaraldehyde is one of the most efficient cross-linking agents. However, the unreacted molecules can be released from the material and cause cytotoxic reactions. Thus, the aim of our work was to investigate the influence of a safer, macromolecular cross-linking agent--dialdehyde starch (DAS). The properties of hydrogels based on collagen/elastin mixtures (95/5, 90/10) containing 5 and 10% of DAS and neutralized via dialysis against deionized water were tested. The homogenous, transparent, stiff hydrogels were obtained. The DAS addition causes the formation of intermolecular cross-linking bonds but does not affect the secondary structure of the proteins. As a result, the thermal stability, mechanical strength, and, surprisingly, swelling ability increased. At the same time, the surface properties test and in vitro study show that the materials are attractive for 3T3 cells. Moreover, the materials containing 10% of DAS are more resistant to enzymatic degradation.
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