Evidence map›Paper›PMID 26886627›Full record

Observational studyMedicine2016

A Novel and Validated Inflammation-Based Score (IBS) Predicts Survival in Patients With Hepatocellular Carcinoma Following Curative Surgical Resection: A STROBE-Compliant Article.

Yi-Peng Fu, Xiao-Chun Ni, Yong Yi, Xiao-Yan Cai, Hong-Wei He, Jia-Xing Wang, Zhu-Feng Lu, Xu Han, Ya Cao, Jian Zhou and 2 more

Open access · goldAbstract readComparative StudyObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yi-Peng FuFrom the Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School (Y-PF, X-CN, YY, X-YC, H-WH, J-XW, Z-FL, JZ, JF, S-JQ) and Biomedical Research Center, Zhongshan Hospital (XH, S-JQ), Fudan University; Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education (Y-PF, X-CN, YY, X-YC, H-WH, J-XW, Z-FL, JZ, JF, S-JQ), Shanghai, P.R. China; and Cancer Research Institute, Xiangya School of Medicine, Central South University (YC), Hunan, China.
Xiao-Chun Ni
Yong Yi
Xiao-Yan Cai
Hong-Wei He
Jia-Xing Wang
Zhu-Feng Lu
Xu Han
Ya Cao
Jian Zhou
Jia Fan
Shuang-Jian Qiu
Bridge University · SS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As chronic inflammation is involved in the pathogenesis and progression of hepatocellular carcinoma (HCC), we investigated the prognostic accuracy of a cluster of inflammatory scores, including the Glasgow Prognostic Score, modified Glasgow Prognostic Score, platelet to lymphocyte ratio, Prognostic Nutritional Index, Prognostic Index, and a novel Inflammation-Based Score (IBS) integrated preoperative and postoperative neutrophil to lymphocyte ratio in 2 independent cohorts. Further, we aimed to formulate an effective prognostic nomogram for HCC after hepatectomy.Prognostic value of inflammatory scores and Barcelona Clinic Liver Cancer (BCLC) stage were studied in a training cohort of 772 patients with HCC underwent hepatectomy. Independent predictors of survival identified in multivariate analysis were validated in an independent set of 349 patients with an overall similar clinical feature.In both training and validation cohorts, IBS, microscopic vascular invasion, and BCLC stage emerged as independent factors of overall survival (OS) and recurrence-free survival (RFS). The predictive capacity of the IBS in both OS and RFS appeared superior to that of the other inflammatory scores in terms of C-index. Additionally, the formulated nomogram comprised IBS resulted in more accurate prognostic prediction compared with BCLC stage alone.IBS is a novel and validated prognostic indicator of HCC after curative resection, and a robust HCC nomogram including IBS was developed to predict survival for patients after hepatectomy.

Indexed as

NomogramsAdolescentAdultAgedAged, 80 and overCarcinoma, HepatocellularChildChinaCohort StudiesFemaleHumansLiver NeoplasmsLymphocyte CountMaleMiddle AgedSeverity of Illness Index

Identifiers

PMID26886627
PMCPMC4998627
OpenAlexW2315620685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.