Evidence map›Paper›PMID 26886282›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Identification of proteins derived from Listeria monocytogenes inducing human dendritic cell maturation.

Reza Mirzaei, Azad Saei, Fatemeh Torkashvand, Bahareh Azarian, Ahmad Jalili, Farshid Noorbakhsh, Behrouz Vaziri, Jamshid Hadjati

Abstract read
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. HarnessingArchives of Razi Institute · 2025
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Reza MirzaeiImmunology Department, School of Medicine, Tehran University of Medical Sciences, Poursina Avenue, Tehran, Iran.
Azad SaeiImmunology Department, School of Medicine, Tehran University of Medical Sciences, Poursina Avenue, Tehran, Iran.
Fatemeh TorkashvandProtein Chemistry Unit, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Bahareh AzarianProtein Chemistry Unit, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Ahmad JaliliDivision of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Farshid NoorbakhshImmunology Department, School of Medicine, Tehran University of Medical Sciences, Poursina Avenue, Tehran, Iran.
Behrouz VaziriProtein Chemistry Unit, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Jamshid HadjatiImmunology Department, School of Medicine, Tehran University of Medical Sciences, Poursina Avenue, Tehran, Iran. hajatij@sina.tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are potent antigen-presenting cells (APCs) that can promote antitumor immunity when pulsed with tumor antigens and then matured by stimulatory agents. Despite apparent progress in DC-based cancer immunotherapy, some discrepancies were reported in generating potent DCs. Listeria monocytogenes as an intracellular microorganism is able to effectively activate DCs through engaging pattern-recognition receptors (PRRs). This study aimed to find the most potent components derived from L. monocytogenes inducing DC maturation. The preliminary results demonstrated that the ability of protein components is higher than DNA components to promote DC maturation and activation. Protein lysate fractionation demonstrated that fraction 2 HIC (obtained by hydrophobic interaction chromatography) was able to efficiently mature DCs. F2HIC-matured DCs are able to induce allogeneic CD8(+) T cells proliferation better than LPS-matured DCs and induce IFN-γ producing CD8(+) T cells. Mass spectrometry results showed that F2HIC contains 109 proteins. Based on the bioinformatics analysis for these 109 proteins, elongation factor Tu (EF-Tu) could be considered as a PRR ligand for stimulating DC maturation.

Indexed as

Bacterial ProteinsCell DifferentiationCell LineDendritic CellsFlow CytometryHumansImmunotherapyListeria monocytogenesLymphocyte ActivationLymphocyte Culture Test, MixedPeptide Elongation Factor TuReceptors, Pattern RecognitionBacterial ProteinsPeptide Elongation Factor TuReceptors, Pattern RecognitionDendritic cellElongation factor TuListeria monocytogenesTumor

Identifiers

PMID26886282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.