ArticleArchives of endocrinology and metabolism2016
TSH reference values in the first trimester of gestation and correlation between maternal TSH and obstetric and neonatal outcomes: a prospective Brazilian study.
Article in Archives of endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Pregnancy outcome in subclinical hypothyroidism with and without thyroid peroxidase antibodies-a prospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Defining Trimester-Specific Reference Intervals for Thyroid Hormones: Insights from a Bulgarian Monocenter Study.Medicina (Kaunas, Lithuania) · 2024Article
- Emerging research themes in maternal hypothyroidism: a bibliometric exploration.Frontiers in immunology · 2024Review
- Article
- [Thyroid function of first-trimester twin pregnant women and its association with preterm delivery].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women.Journal of clinical medicine · 2020Article
- Effects of Maternal Subclinical Hypothyroidism in Early Pregnancy Diagnosed by Different Criteria on Adverse Perinatal Outcomes in Chinese Women With Negative TPOAb.Frontiers in endocrinology · 2020Article
- Effect of mildly elevated thyroid-stimulating hormone during the first trimester on adverse pregnancy outcomes.BMC endocrine disorders · 2018Article
- Region-specific reference intervals for TSH in pregnancy: time for changes in Brazil.Archives of endocrinology and metabolism · 2018Article
- Recent recommendations from ATA guidelines to define the upper reference range for serum TSH in the first trimester match reference ranges for pregnant women in Rio de Janeiro.Archives of endocrinology and metabolism · 2018Article
- Maternal thyroid-stimulating hormone reference ranges for first trimester screening from 11 to 14 weeks of gestation.Journal of clinical laboratory analysis · 2018Article
- Maternal hypothyroxinemia in the first trimester of gestation and association with obstetric and neonatal outcomes and iron deficiency: a prospective Brazilian study.Archives of endocrinology and metabolism · 2018Article
- Selective screening for thyroid dysfunction in pregnant women: How often do low-risk women cease to be treated following the new guidelines of the American Thyroid Association?Archives of endocrinology and metabolism · 2018Article
- Are TSH normal reference ranges adequate for pregnant women?Archives of endocrinology and metabolism · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo define the normal range of TSH in the first trimester of gestation and to evaluate the correlation between maternal TSH and obstetric and neonatal outcomes. SUBJECTS AND
methodsProspective study. Women without known or clinically suspected thyroid disease and without risk factors for thyroid dysfunction, who became pregnant spontaneously and were initially evaluated up to week 12 of gestation, were included. Women with positive anti-thyroperoxidase antibodies, twin pregnancy, hyperemesis gravidarum, and trophoblastic disease were excluded.
resultsIn the 660 pregnant women, the mean, median, and 2.5th and 97.5th percentiles of TSH were 0.9, 0.96, 0.04 and 2.68 mIU/L, respectively. TSH was undetectable in 2%, < 0.5 mIU/L in 17.4%, > 2 mIU/L in 9.7%, > 2.5 mIU/L in 4.7%, and > 3 mIU/L in 1%. None of the women received levothyroxine or antithyroid drugs during pregnancy. In addition, there was no difference in obstetric or neonatal outcomes when women with TSH ≤ 0.1, between 0.1 and 2.5, and between 2.5 and 4 mIU/L were compared.
conclusionIn the population studied, the TSH value corresponding to the 97.5th percentile was 2.68 mIU/L in the first trimester of gestation.
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