ArticleRedox report : communications in free radical research2016
Increased oxidative stress in children with attention deficit hyperactivity disorder.
Article in Redox report : communications in free radical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Multinutrients Decrease Oxidative Stress in Children With ADHD: Mediation/Moderation Analysis of Randomized Controlled Trial Data.Journal of attention disorders · 2025Trial
- Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit Hyperactivity Disorder.International journal of clinical practice · 2022Trial
- Trial
- Targeted and Untargeted Urinary Metabolomic Analyses of Organophosphate Pesticides Exposure and Attention-Deficit/Hyperactivity Disorder in Children.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Mitochondrial Dysfunction in Autism and Attention-Deficit/Hyperactivity Disorder: Evidence from Genetic, Biochemical, and Neuroimaging Approaches.Antioxidants (Basel, Switzerland) · 2026Review
- The immune system's role in attention deficit hyperactivity disorder development.European child & adolescent psychiatry · 2026Article
- Redox Imbalance in ADHD: A Meta-Analysis of Oxidative Stress and Antioxidant Biomarkers (2010-2025).Clinical neuropsychiatry · 2026Article
- Maternal oxidative stress throughout pregnancy and early childhood neurodevelopment at different stages: insights from a prospective cohort study.BMC medicine · 2025Article
- Iranian Traditional Medicine for Treatment of Attention Deficit Disorder with Hyperactivity in Children: A Systematic Review of Randomized Controlled Trials.Iranian journal of public health · 2024Review
- Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months.Developmental psychobiology · 2024Article
- Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review.Neurology and therapy · 2022Review
- Shortened Infant Telomere Length Is Associated with Attention Deficit/Hyperactivity Disorder Symptoms in Children at Age Two Years: A Birth Cohort Study.International journal of molecular sciences · 2022Article
- Article
- Ubiquinone Levels as a Marker of Antioxidant System in Children with Attention Deficit Hyperactivity Disorder.Journal of molecular neuroscience : MN · 2021Article
- Connecting inorganic mercury and lead measurements in blood to dietary sources of exposure that may impact child development.World journal of methodology · 2021Review
- Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders.Antioxidants (Basel, Switzerland) · 2021Article
- Associations between urinary biomarkers of oxidative stress in the third trimester of pregnancy and behavioral outcomes in the child at 4 years of age.Brain, behavior, and immunity · 2020Article
- Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder.Antioxidants (Basel, Switzerland) · 2020Review
- Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder.Antioxidants (Basel, Switzerland) · 2020Review
- ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats.Psychopharmacology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD).
methodsTotal oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls).
resultsAge and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group. DISCUSSION: We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.