Evidence map›Paper›PMID 26885978›Full record

Trial reportPloS one2016

Endurance Exercise Enhances the Effect of Strength Training on Muscle Fiber Size and Protein Expression of Akt and mTOR.

Zuzanna Kazior, Sarah J Willis, Marcus Moberg, William Apró, José A L Calbet, Hans-Christer Holmberg, Eva Blomstrand

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  15. The impact of exercise on sleep and sleep disorders.Npj biological timing and sleep · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zuzanna KaziorSwedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.
Sarah J WillisSwedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.
Marcus MobergSwedish School of Sport and Health Sciences, Stockholm, Sweden.
William ApróSwedish School of Sport and Health Sciences, Stockholm, Sweden.
José A L CalbetDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Hans-Christer HolmbergSwedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.
Eva BlomstrandSwedish School of Sport and Health Sciences, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reports concerning the effect of endurance exercise on the anabolic response to strength training have been contradictory. This study re-investigated this issue, focusing on training effects on indicators of protein synthesis and degradation. Two groups of male subjects performed 7 weeks of resistance exercise alone (R; n = 7) or in combination with preceding endurance exercise, including both continuous and interval cycling (ER; n = 9). Muscle biopsies were taken before and after the training period. Similar increases in leg-press 1 repetition maximum (30%; P<0.05) were observed in both groups, whereas maximal oxygen uptake was elevated (8%; P<0.05) only in the ER group. The ER training enlarged the areas of both type I and type II fibers, whereas the R protocol increased only the type II fibers. The mean fiber area increased by 28% (P<0.05) in the ER group, whereas no significant increase was observed in the R group. Moreover, expression of Akt and mTOR protein was enhanced in the ER group, whereas only the level of mTOR was elevated following R training. Training-induced alterations in the levels of both Akt and mTOR protein were correlated to changes in type I fiber area (r = 0.55-0.61, P<0.05), as well as mean fiber area (r = 0.55-0.61, P<0.05), reflecting the important role played by these proteins in connection with muscle hypertrophy. Both training regimes reduced the level of MAFbx protein (P<0.05) and tended to elevate that of MuRF-1. The present findings indicate that the larger hypertrophy observed in the ER group is due more to pronounced stimulation of anabolic rather than inhibition of catabolic processes.

Indexed as

ExercisePhysical EnduranceResistance TrainingAdultBiopsyHumansMaleMuscle Fibers, SkeletalMuscle ProteinsMuscle StrengthOxygen ConsumptionProto-Oncogene Proteins c-aktRNA, MessengerSignal TransductionTOR Serine-Threonine KinasesMuscle ProteinsProto-Oncogene Proteins c-aktRNA, MessengerTOR Serine-Threonine Kinases

Identifiers

PMID26885978
PMCPMC4757413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.