Evidence map›Paper›PMID 26885769›Full record

ArticleBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2016

High Rates of Exclusive Breastfeeding in Both Arms of a Peer Counseling Study Promoting EBF Among HIV-Infected Kenyan Women.

Rose Bosire, Bourke Betz, Adam Aluisio, James P Hughes, Ruth Nduati, James Kiarie, Bhavna H Chohan, Michele Merkel, Barbara Lohman-Payne, Grace John-Stewart and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Rose Bosire1 Kenya Medical Research Institute , Nairobi, Kenya .
Bourke Betz3 Department of Epidemiology, University of Washington , Seattle, Washington.
Adam Aluisio4 Department of Emergency Medicine, Warren Alpert School of Medicine, Brown University , Providence, Rhode Island.
James P Hughes5 Department of Biostatistics, University of Washington , Seattle, Washington.
Ruth Nduati6 Department of Pediatrics, University of Nairobi , Nairobi, Kenya .
James Kiarie7 Department of Obstetrics, and Gynecology, University of Nairobi , Nairobi, Kenya .
Bhavna H Chohan1 Kenya Medical Research Institute , Nairobi, Kenya .
Michele Merkel11 Global Scientific Solutions for Health , Baltimore, Maryland.
Barbara Lohman-Payne12 Institute for Immunology and Informatics, University of Rhode Island , Providence, Rhode Island.
Grace John-Stewart3 Department of Epidemiology, University of Washington , Seattle, Washington.
Carey Farquhar3 Department of Epidemiology, University of Washington , Seattle, Washington.
University of Washington · USUniversity of Nairobi · KEBrown University · USKarolinska Institutet · SEUniversity of Rhode Island · US

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
Impact of counseling on breastfeeding practice and infant HIV-1 transmissionR01TW007629 · FIC · KENYA MEDICAL RESEARCH INSTITUTE (KEMRI) · PI BOSIRE, ROSE KERUBO OTISO · 2007 to 2011
$253k
FIC NIH HHS FIC D43 TW000007FIC NIH HHS FIC R24 TW007988FIC NIH HHS R01 TW007629NIAID NIH HHS NIH K24 AI087399NICHD NIH HHS K24 HD054314NICHD NIH HHS NIH K24 HD 054314
6 · The paper itself

Abstract

backgroundExclusive breastfeeding (EBF) is recommended for 6 months after delivery as the optimal infant feeding method and is especially important for prevention of mother-to-child HIV transmission (PMTCT). However, EBF promotion efforts among HIV-infected mothers in sub-Saharan Africa have achieved mixed success and require context-specific interventions.

methodsHIV-positive, pregnant women from six clinics in Nairobi were enrolled into a clinic-level, before-after counseling intervention study. All women received standard perinatal and HIV care. Women in the intervention arm were offered three counseling sessions that promoted EBF, described its benefits, and explained breastfeeding techniques. Mother-infant pairs were followed until 14 weeks postpartum, with infant HIV testing at 6 weeks. EBF prevalence at 14 weeks postpartum was compared between study arms using log-binomial regression. Proportions of 6-week HIV-free survival and 14-week infant survival were assessed using Cox regression. Risk estimates were adjusted for clinic, relationship status, and antiretroviral therapy.

resultsBetween 2009 and 2013, 833 women were enrolled of whom 94% planned to practice EBF for 6 months and 95% were taking therapeutic or prophylactic antiretrovirals. Median age was 27 years; median CD4 count was 403 cells/μL. EBF prevalence at 14 weeks postpartum was 86% in the control and 81% in the intervention group (p = 0.19). No differences were observed between groups for 6-week HIV-free survival and 14-week infant survival.

conclusionWomen who received breastfeeding counseling were not more likely to breastfeed exclusively, in part due to high overall EBF prevalence in this study population. The high EBF prevalence is an important finding, given recent efforts to promote EBF in Kenya.

Indexed as

MothersAdultAntiretroviral Therapy, Highly ActiveBreast FeedingCD4 Lymphocyte CountDirective CounselingFemaleFollow-Up StudiesHealth PromotionHIV InfectionsHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaInfectious Disease Transmission, VerticalKenya

Identifiers

PMID26885769
PMCPMC4782034
OpenAlexW2283781929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.