ArticleOncotarget2016
Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- RETRACTED: Effects of exercise in treating patients with venous leg ulcers: An umbrella review.International wound journal · 2024Pooled it
- Is exercise a senolytic medicine? A systematic review.Aging cell · 2021Pooled it
- The role of tendon and ligament vasculature in ageing and injury.Biogerontology · 2026Review
- Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging.Nature communications · 2026Article
- Regenerative effects of secretome from tendon-derived stem cells and treadmill training on Achilles tendon healing in rats.Histochemistry and cell biology · 2026Article
- On the Merits of Targeted and Individualized Physical Exercise in Persons with Diabetic Foot Disease-From Controversies to Consensus.Biomedicines · 2025Review
- Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair.Bioactive materials · 2025Review
- Targeting Senescent Tendon Stem/Progenitor Cells to Prevent or Treat Age-Related Tendon Disorders.Stem cell reviews and reports · 2023Review
- Impact of elevated serum advanced glycation end products and exercise on intact and injured murine tendons.Connective tissue research · 2023Article
- Exercise sustains the hallmarks of health.Journal of sport and health science · 2023Review
- The role of loading in murine models of rotator cuff disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy.International journal of molecular sciences · 2022Review
- Effects of aging on the histology and biochemistry of rat tendon healing.BMC musculoskeletal disorders · 2021Article
- Characterization of Tendon-Derived Stem Cells and Rescue Tendon Injury.Stem cell reviews and reports · 2021Review
- Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells.Frontiers in cell and developmental biology · 2021Article
- Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries.Tissue engineering. Part B, Reviews · 2020Review
- Role of Mechanical Loading for Platelet-Rich Plasma-Treated Achilles Tendinopathy.Current sports medicine reports · 2020Review
- AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.Cell death & disease · 2020Article
- Exercise influences the impact of polychlorinated biphenyl exposure on immune function.PloS one · 2020Article
- Use of adult mesenchymal stromal cells in tissue repair: impact of physical exercise.American journal of physiology. Cell physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
The effect of exercise on wound healing in aging tendon was tested using a rat moderate treadmill running (MTR) model. The rats were divided into an MTR group that ran on a treadmill for 4 weeks and a control group that remained in cages. After MTR, a window defect was created in the patellar tendons of all rats and wound healing was analyzed. We found that MTR accelerated wound healing by promoting quicker closure of wounds, improving the organization of collagen fibers, and decreasing senescent cells in the wounded tendons when compared to the cage control. MTR also lowered vascularization, increased the numbers of tendon stem/progenitor cells (TSCs) and TSC proliferation than the control. Besides, MTR significantly increased the expression of stem cell markers, OCT-4 and Nanog, and tenocyte genes, Collagen I, Collagen III and tenomodulin, and down-regulated PPAR-γ, Collagen II and Runx-2 (non-tenocyte genes). These findings indicated that moderate exercise enhances healing of injuries in aging tendons through TSC based mechanisms, through which exercise regulates beneficial effects in tendons. This study reveals that appropriate exercise may be used in clinics to enhance tendon healing in aging patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.