ArticleMedicine and science in sports and exercise2016
Ovariectomized Highly Fit Rats Are Protected against Diet-Induced Insulin Resistance.
Article in Medicine and science in sports and exercise, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Review
- Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice.Nutrients · 2022Article
- Differential weight loss with intermittent fasting or daily calorie restriction in low- and high-fitness phenotypes.Experimental physiology · 2021Article
- Opposing effects of S-equol supplementation on metabolic and behavioral parameters in mice fed a high-fat diet.Nutrition research (New York, N.Y.) · 2019Article
- Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats.Adipocyte · 2018Article
- Acute and chronic changes in rat soleus muscle after high-fat high-sucrose diet.Physiological reports · 2017Article
- Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats.Medicine and science in sports and exercise · 2017Article
- Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α.Oncotarget · 2016Article
- Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression.Physiology & behavior · 2016Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
introductionIn the absence of exercise training, rats selectively bred for high intrinsic aerobic capacity (high-capacity running (HCR)) are protected against ovariectomy (OVX)-induced insulin resistance (IR) and obesity compared with those bred for low intrinsic aerobic capacity (low-capacity running (LCR)). PURPOSE: This study determined whether OVX HCR rats remain protected with exposure to high-fat diet (HFD) compared with OVX LCR rats.
methodsFemale HCR and LCR rats (n = 36; age, 27-33 wk) underwent OVX and were randomized to a standard chow diet (NC, 5% kcal fat) or HFD (45% kcal fat) ad libitum for 11 wk. Total energy expenditure, resting energy expenditure, spontaneous physical activity (SPA), and glucose tolerance were assessed midway, whereas fasting circulating metabolic markers, body composition, adipose tissue distribution, and skeletal muscle adenosine monophosphate-activated protein kinase (AMPK), and mitochondrial markers were assessed at sacrifice.
resultsBoth HCR and LCR rats experienced HFD-induced increases in total and visceral adiposity after OVX. Despite similar gains in adiposity, HCR rats were protected from HFD-induced IR and reduced total energy expenditure observed in LCR rats (P < 0.05). This metabolic protection was likely attributed to a compensatory increase in SPA and associated preservation of skeletal muscle AMPK activity in HCR; however, HFD significantly reduced SPA and AMPK activity in LCR (P < 0.05). In both lines, HFD reduced citrate synthase activity, gene expression of markers of mitochondrial biogenesis (tFAM, NRF1, and PGC-1α), and protein levels of mitochondrial oxidative phosphorylation complexes I, II, IV, and V in skeletal muscle (all P < 0.05).
conclusionAfter OVX, HCR and LCR rats differentially respond to HFD such that HCR increase while LCR decrease SPA. This "physical activity compensation" likely confers protection from HFD-induced IR and reduced energy expenditure in HCR rats.
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