ArticleJournal of vision2016
Degraded attentional modulation of cortical neural populations in strabismic amblyopia.
Article in Journal of vision, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 64 citations in OpenAlex.
- Feasibility of EEG-based machine learning for the objective assessment of non-Strabismic binocular vision dysfunction.Frontiers in human neuroscience · 2026Article
- Slow binocular reading during rapid serial visual presentation (RSVP) in children with amblyopia and the role of fixation instability.Vision research · 2025Article
- Association between amblyopia and benign paroxysmal positional vertigo: nationwide cohort study.Scientific reports · 2025Article
- Differential Impacts of Strabismic and Anisometropic Amblyopia on the Mesoscale Functional Organization of the Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Monocular eye-cueing shifts eye balance in amblyopia.Journal of vision · 2025Article
- Decreased scene-selective activity within the posterior intraparietal cortex in amblyopic adults.Frontiers in neuroscience · 2025Article
- Deficits of the "Good" Eye in Amblyopia: Processing Geometric Properties.Investigative ophthalmology & visual science · 2024Article
- Decreased scene-selective activity within the posterior intraparietal cortex in amblyopic adults.bioRxiv : the preprint server for biology · 2024Article
- Article
- Collective plasticity of binocular interactions in the adult visual system.Scientific reports · 2024Article
- Using high-resolution functional MRI to differentiate impacts of strabismic and anisometropic amblyopia on evoked ocular dominance activity in humans.bioRxiv : the preprint server for biology · 2024Article
- Flash Suppression Reveals an Additional Nonvisual Extrastriate Contribution for Amblyopic Suppression.Investigative ophthalmology & visual science · 2024Article
- Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies.Neural regeneration research · 2023Article
- Deficits in Reach Planning and On-Line Grasp Control in Adults With Amblyopia.Investigative ophthalmology & visual science · 2023Article
- The Suppressive Basis of Ocular Dominance Changes Induced by Short-Term Monocular Deprivation in Normal and Amblyopic Adults.Investigative ophthalmology & visual science · 2023Article
- Dissociable Neural Mechanisms Underlie the Effects of Attention on Visual Appearance and Response Bias.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Stereoptic serious games as a visual rehabilitation tool for individuals with a residual amblyopia (AMBER trial): a protocol for a crossover randomized controlled trial.BMC ophthalmology · 2023Article
- The role of binocular vision in the control and development of visually guided upper limb movements.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Perceptual learning with dichoptic attention tasks improves attentional modulation in V1 and IPS and reduces interocular suppression in human amblyopia.Scientific reports · 2022Article
- Exogenous attention generalizes location transfer of perceptual learning in adults with amblyopia.iScience · 2022Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Behavioral studies have reported reduced spatial attention in amblyopia, a developmental disorder of spatial vision. However, the neural populations in the visual cortex linked with these behavioral spatial attention deficits have not been identified. Here, we use functional MRI-informed electroencephalography source imaging to measure the effect of attention on neural population activity in the visual cortex of human adult strabismic amblyopes who were stereoblind. We show that compared with controls, the modulatory effects of selective visual attention on the input from the amblyopic eye are substantially reduced in the primary visual cortex (V1) as well as in extrastriate visual areas hV4 and hMT+. Degraded attentional modulation is also found in the normal-acuity fellow eye in areas hV4 and hMT+ but not in V1. These results provide electrophysiological evidence that abnormal binocular input during a developmental critical period may impact cortical connections between the visual cortex and higher level cortices beyond the known amblyopic losses in V1 and V2, suggesting that a deficit of attentional modulation in the visual cortex is an important component of the functional impairment in amblyopia. Furthermore, we find that degraded attentional modulation in V1 is correlated with the magnitude of interocular suppression and the depth of amblyopia. These results support the view that the visual suppression often seen in strabismic amblyopia might be a form of attentional neglect of the visual input to the amblyopic eye.
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