Evidence map›Paper›PMID 26885543›Full record

ArticleOpen forum infectious diseases2016

Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258.

Sorabh Dhar, Emily T Martin, Paul R Lephart, John P McRoberts, Teena Chopra, Timothy T Burger, Ruthy Tal-Jasper, Kayoko Hayakawa, Hadas Ofer-Friedman, Tsilia Lazarovitch and 5 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Within patient genetic diversity of blaScientific reports · 2021
    Article
  3. Risk Factors for and Mechanisms ofOpen forum infectious diseases · 2021
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sorabh DharDepartment of Medicine, Division of Infectious Diseases , Wayne State University , Detroit, Michigan.
Emily T MartinDepartment of Epidemiology , University of Michigan School of Public Health , Detroit.
Paul R LephartDepartment of Clinical Microbiology , Detroit Medical Center, Wayne State University , Michigan.
John P McRobertsDepartment of Epidemiology , University of Michigan School of Public Health , Detroit.
Teena ChopraDepartment of Medicine, Division of Infectious Diseases , Wayne State University , Detroit, Michigan.
Timothy T BurgerDepartment of Clinical Microbiology , Detroit Medical Center, Wayne State University , Michigan.
Ruthy Tal-JasperSackler School of Medicine , Tel-Aviv University.
Kayoko HayakawaDepartment of Medicine, Division of Infectious Diseases , Wayne State University , Detroit, Michigan.
Hadas Ofer-FriedmanDivision of Infectious Diseases , Assaf Harofeh Medical Center.
Tsilia LazarovitchDepartment of Clinical Microbiology , Assaf Harofeh Medical Center , Zerifin , Israel.
Ronit ZaidensteinDivision of Infectious Diseases , Assaf Harofeh Medical Center.
Federico PerezResearch Service, Case Western Reserve University, Cleveland; VISN 10 Geriatric Research, Education, and Clinical Center (GRECC) at Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University.
Robert A BonomoResearch Service, Case Western Reserve University, Cleveland; VISN 10 Geriatric Research, Education, and Clinical Center (GRECC) at Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University; Departments ofMedicine; Pharmacology; Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio.
Keith S KayeDepartment of Medicine, Division of Infectious Diseases , Wayne State University , Detroit, Michigan.
Dror MarchaimSackler School of Medicine, Tel-Aviv University; Division of Infectious Diseases, Assaf Harofeh Medical Center.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
Defining Precursors to VRSA Emergence: Epidemiology of MRSA & VRE Dual InfectionK01AI099006 · NIAID · WAYNE STATE UNIVERSITY · PI MARTIN, EMILY TOTH · 2012 to 2016
$641k
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniaeR21AI114508 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., VAN DUIN, DAVID · 2015 to 2016
$445k
NCATS NIH HHS UL1 TR000439NIAID NIH HHS K01 AI099006NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI100560NIAID NIH HHS R21 AI114508
6 · The paper itself

Abstract

A "high risk" clone of carbapenem-resistant Klebsiella pneumoniae (CRKP) identified by multilocus sequence typing (MLST) as sequence type (ST) 258 has disseminated worldwide. As the molecular epidemiology of the CRE pandemic continues to evolve, the clinical impact of non-ST258 strains is less well defined. We conducted an epidemiological investigation of CRKP based on strains MLST. Among 68 CRKP patients, 61 were ST258 and 7 belonged to non-ST258. Klebsiella pneumoniae ST258 strains were significantly associated with bla KPC production and with resistance to an increased number of antimicrobials. Clinical outcomes were not different. Based on this analysis, one cannot rely solely on the presence of bla KPC in order to diagnose CRKP.

Indexed as

CREKPCMDROoutcomerisk factors

Identifiers

PMID26885543
PMCPMC4751918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.