Evidence map›Paper›PMID 26885471›Full record

ArticleKidney research and clinical practice2014

Significance of residual renal function for phosphate control in chronic hemodialysis patients.

Harin Rhee, Ji Young Yang, Woo Jin Jung, Min Ji Shin, Byung Yoon Yang, Sang Heon Song, Ihm Soo Kwak, Eun Young Seong

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Article in Kidney research and clinical practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
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11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Harin RheeDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Ji Young YangBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Woo Jin JungDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Min Ji ShinDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Byung Yoon YangDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Sang Heon SongDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Ihm Soo KwakDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Eun Young SeongDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to compare mineral metabolism between anuric and nonanuric chronic hemodialysis patients, and determine the differences in phosphate control between the two groups.

methodsA total of 77 chronic hemodialysis patients were enrolled in this cross-sectional study from January 2012 to February 2012. Patient demographics, laboratory findings, medication histories, and vascular calcification scores were collected. We divided the patients into anuric and nonanuric groups according to the residual renal function and then compared their clinical features. Multivariate binary regression analysis was used in each group to determine the independent factors related to phosphate control.

resultsThe mean patient age was 59.27±13.95 years, and 57.1% of patients were anuric. In anuric patients, dialysis vintage was significantly longer, but the mean Kt/V was not different between groups. Serum phosphate, fibroblast growth factor (FGF)-23, and Ca/P products were significantly higher, and 1,25(OH)2D3 levels were significantly lower in the anuric patients, although the intact parathyroid hormone and 25(OH)D levels were not different. In anuric patients, LnFGF-23 [hazard ratio (HR) 2.894, 95% confidence interval (CI) 1.294-6.474, P=0.010] was an independent factor predictive of phosphate control. However, in the nonanuric patients, glomerular filtration rate (HR 0.409, 95% CI 0.169-0.989, P=0.047) and blood urea nitrogen (HR 1.090, 95% CI 1.014-1.172, P=0.019) were independent factors predictive of phosphate control.

conclusionIn chronic hemodialysis patients, preservation of residual renal function is a significant determinant of phosphate control, and the factors associated with phosphate control is different depending on the residual renal function status. In the anuric patients, FGF-23 is most significantly associated with phosphate control; however, glomerular filtration rate and blood urea nitrogen are more important than FGF-23 in the nonanuric HD patients.

Indexed as

End-stage renal diseaseHemodialysisMineral metabolismPhosphate controlResidual renal function

Identifiers

PMID26885471
PMCPMC4714245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.