ReviewNeural plasticity2016
Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis.
Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.Frontiers in psychiatry · 2021Pooled it
- Social Anxiety and Sensation-seeking Tendencies in Young Adults.Annals of neurosciences · 2026Article
- Climate anxiety among nursing students: a scoping review.BMC nursing · 2026Article
- Impaired WNT3/IGF-1 Signaling in Dorsal Dentate Gyrus Contributes to Chronic Pain-Related Cognitive Impairment.CNS neuroscience & therapeutics · 2025Article
- Ameliorative Effect of Moringa oleifera Against CUMS-Induced Anxiety in Rats: β-Catenin and 5-HTMolecular neurobiology · 2025Article
- Anxiolytic effect of zinc oxide gallic acid composite nanoparticles following D-galactose administration in rats.Scientific reports · 2025Article
- Gender differences in the association between anxiety symptoms and thyroid hormones in young patients with first-episode and drug naïve major depressive disorder.Frontiers in psychiatry · 2023Article
- Polysubstance Use, Mood Disorders, and Chronic Conditions With Anxiety in Opioid Patients.Western journal of nursing research · 2022Article
- Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of theCells · 2022Article
- Gender differences in Anxious-depressive symptomatology, Metabolic Syndrome and Colorectal Adenomas among outpatients undergoing colonoscopy: a cross-sectional study according to a PNEI perspective.Acta bio-medica : Atenei Parmensis · 2022Article
- Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval.Scientific reports · 2022Article
- Individual Patterns and Temporal Trajectories of Changes in Fear and Pain during Exposure In Vivo: A Multiple Single-Case Experimental Design in Patients with Chronic Pain.Journal of clinical medicine · 2022Article
- Association of Sources of Worry and Stress with Smoking in Japan: Findings from the Comprehensive Survey of Living Conditions 2010.Juntendo Iji zasshi = Juntendo medical journal · 2022Article
- The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.International journal of molecular sciences · 2021Article
- Co-treatment of vitamin D supplementation with enriched environment improves synaptic plasticity and spatial learning and memory in aged rats.Psychopharmacology · 2021Article
- Preoperative anxiety among Iranian adult patients undergoing elective surgeries in educational hospitals.Journal of education and health promotion · 2021Article
- Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study.Frontiers in aging neuroscience · 2021Article
- Girls' Stuff? Maternal Gender Stereotypes and Their Daughters' Fear.Frontiers in psychology · 2021Article
- Use of an Animal Model to Evaluate Anxiolytic Effects of Dietary Supplementation withNutrients · 2020Article
- Emotionality modulates the impact of chronic stress on memory and neurogenesis in birds.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the literature reports a higher incidence of anxiety disorders in women, the majority of basic research has focused on male rodents, thus resulting in a lack of knowledge on the neurobiology of anxiety in females. Bridging this gap is crucial for the design of effective translational interventions in women. One of the key brain mechanisms likely to regulate anxious behavior is adult hippocampal neurogenesis (AHN). This review paper aims to discuss the evidence on the differences between male and female rodents with regard to anxiety-related behavior and physiology, with a special focus on AHN. The differences between male and female physiologies are greatly influenced by hormonal differences. Gonadal hormones and their fluctuations during the estrous cycle have often been identified as agents responsible for sexual dimorphism in behavior and AHN. During sexual maturity, hormone levels fluctuate cyclically in females more than in males, increasing the stress response and the susceptibility to anxiety. It is therefore of great importance that future research investigates anxiety and other neurophysiological aspects in the female model, so that results can be more accurately applicable to the female population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.