Clinicopathological significance of NGX6 expression in breast cancer and its relationship to angiogenesis.

Jidong Xiao, Yuyao Mao, Yuanquan Zhou, Kaimin Xiang

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Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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1 citing paper in PubMed, 1 citations in OpenAlex.

The Role of the Transcription Factor EGR1 in Cancer.Frontiers in oncology · 2021
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5 · Who and what money

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4 authors at 1 institution in 1 country.

Jidong XiaoDepartment of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

Yuyao MaoDepartment of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

Yuanquan ZhouDepartment of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

Kaimin XiangDepartment of General Surgery, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim was to explore clinicopathological significance of Nasopharyngeal carcinoma-associated gene 6 (NGX6) expression in breast cancer and its relationship to angiogenesis.

methodsClinicopathological feature of 168 patients with breast cancer were analyzed. NGX6 expression and microvessel density (MVD) in tumor tissue were measured using immunohistochemistry methods. The association of NGX6 expression with MVD and clinicopathological features was assessed.

resultsAmong 168 cases of breast cancer, NGX6 positive expression were found in 92 (54.8%) cases and NGX6 negative expression were found in 76 (45.2%) cases. Incidence rate of large size tumor, high tumor node metastasis (TNM) stage and lymph node metastasis in NGX6 negative expression group were higher than NGX6 positive expression group in breast cancer (P=0.003, 0.007, and 0.003, respectively). MVD in NGX6 negative expression group is 22.5±4.8, MVD in NGX6 positive expression group is 15.2±4.2. MVD in the NGX6 negative expression group was significantly higher than the NGX6 positive expression group (P<0.05).

conclusionThe expression of NGX6 was closely associated with tumor size, TNM stage, lymph node metastasis and MVD. NGX6 is involved in metastasis and angiogenesis activity of breast cancer. The study may provide a theoretical basis for anti-angiogenic therapy of breast cancer.

Indexed as

angiogenesisBreast cancermetastasisnasopharyngeal carcinoma associated gene 6 (NGX6)

Identifiers

PMID26885195

PMCPMC4729981

OpenAlexW2278581205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.